文章：

鼻咽癌精准医疗——当前预后策略综述

Precision Medicine for Nasopharyngeal Cancer—A Review of Current Prognostic Strategies

原文发布日期：24 February 2024

DOI: 10.3390/cancers16050918

类型: Article

开放获取: 是

英文摘要：

Nasopharyngeal carcinoma (NPC) is an Epstein–Barr virus (EBV) driven malignancy arising from the nasopharyngeal epithelium. Current treatment strategies depend on the clinical stage of the disease, including the extent of the primary tumour, the extent of nodal disease, and the presence of distant metastasis. With the close association of EBV infection with NPC development, EBV biomarkers have shown promise in predicting treatment outcomes. Among the omic technologies, RNA and miRNA signatures have been widely studied, showing promising results in the research setting to predict treatment response. The transformation of radiology images into measurable features has facilitated the use of radiomics to generate predictive models for better prognostication and treatment selection. Nonetheless, much of this work remains in the research realm, and challenges remain in clinical implementation.

摘要翻译： 

鼻咽癌是一种由爱泼斯坦-巴尔病毒驱动的恶性肿瘤，起源于鼻咽上皮。当前的治疗策略取决于疾病的临床分期，包括原发肿瘤范围、淋巴结病变程度以及是否存在远处转移。由于EBV感染与鼻咽癌发生密切相关，EBV生物标志物在预测治疗效果方面展现出潜力。在多组学技术中，RNA和miRNA特征谱已得到广泛研究，在预测治疗反应的研究场景中显示出良好前景。将放射影像转化为可量化特征的技术促进了放射组学的发展，使其能够构建预测模型以优化预后评估和治疗选择。然而，该领域大部分研究仍处于探索阶段，临床转化应用仍面临诸多挑战。

原文链接：

Precision Medicine for Nasopharyngeal Cancer—A Review of Current Prognostic Strategies