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文章:

迈向简化且经济有效的导管内乳头状黏液性肿瘤(IPMN)监测诊断算法:我们能否将造影剂留待后续使用?

Towards a Simplified and Cost-Effective Diagnostic Algorithm for the Surveillance of Intraductal Papillary Mucinous Neoplasms (IPMNs): Can We Save Contrast for Later?

原文发布日期:23 February 2024

DOI: 10.3390/cancers16050905

类型: Article

开放获取: 是

 

英文摘要:

The increased detection of pancreatic cysts in recent years has triggered extensive diagnostic investigations to clarify their potential risk of malignancy, resulting in a large number of patients undergoing numerous imaging follow-up studies for many years. Therefore, there is a growing need for optimization of the current surveillance protocol to reduce both healthcare costs and waiting lists, while still maintaining appropriate sensibility and specificity. Imaging is an essential tool for evaluating patients with intraductal papillary mucinous neoplasms (IPMNs) since it can assess several predictors for malignancy and thus guide further management recommendations. Although contrast-enhanced magnetic resonance imaging (MRI) with magnetic resonance cholangiopancreatography (MRCP) has been widely recommended by most international guidelines, recent results support the use of unenhanced abbreviated-MRI (A-MRI) protocols as a surveillance tool in patients with IPMN. In fact, A-MRI has shown high diagnostic performance in malignant detection, with high sensitivity and specificity as well as excellent interobserver agreement. The aim of this paper is, therefore, to discuss the current available evidence on whether the implementation of an abbreviated-MRI (A-MRI) protocol for cystic pancreatic lesion surveillance could improve healthcare economics and reduce waiting lists in clinical practice without significantly reducing diagnostic accuracy.

 

摘要翻译: 

近年来胰腺囊肿检出率的增加引发了广泛的诊断性检查,以明确其潜在的恶性风险,导致大量患者需接受多年的多次影像学随访。因此,优化现有监测方案的需求日益增长,以期在保持适当敏感性和特异性的同时,降低医疗成本并缩短候诊时间。影像学是评估导管内乳头状黏液性肿瘤(IPMN)患者的重要工具,因其可评估多种恶性预测因素,从而指导进一步的治疗建议。尽管大多数国际指南广泛推荐使用增强磁共振成像(MRI)联合磁共振胰胆管成像(MRCP),但近期研究结果支持将非增强简化MRI(A-MRI)方案作为IPMN患者的监测手段。事实上,A-MRI在恶性病变检测中展现出较高的诊断效能,具有高敏感性和特异性以及优异的观察者间一致性。因此,本文旨在探讨现有证据,分析在胰腺囊性病变监测中采用简化MRI(A-MRI)方案是否能在不显著降低诊断准确性的前提下,改善医疗经济性并缩短临床实践中的候诊时间。

 

原文链接:

Towards a Simplified and Cost-Effective Diagnostic Algorithm for the Surveillance of Intraductal Papillary Mucinous Neoplasms (IPMNs): Can We Save Contrast for Later?

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