Prostate cancer (PC) is a major global public health concern, imposing a significant burden on men and ranking as the second most prevalent malignancy. This study delves into the intricate world of ubiquitination processes and expression regulation, with a specific focus on understanding the roles of ubiquitin B (UBB), ubiquitin C (UBC), and β-Catenin in PC development. We thoroughly analyze the expression profiles of UBB, UBC, and β-Catenin, investigating their interactions and associations with clinical and histopathological data. These findings offer valuable insights into their potential as robust prognostic markers and their significance for patient survival. Our research uncovers the upregulation of UBB and UBC expression in PC tissues, and an even more pronounced expression in lymph node metastases, highlighting their pivotal roles in PC progression. Moreover, we identify a compelling correlation between high UBB and UBC levels and diminished overall survival in PC patients, emphasizing their clinical relevance. Additionally, we observe a significant reduction in membranous β-Catenin expression in PC tissues. Importantly, abnormal β-Catenin expression is strongly associated with shorter survival in PC patients and serves as a significant, independent prognostic factor for patient outcomes. Kaplan–Meier survival analysis indicates that patients with tumors characterized by simultaneous UBB and aberrant β-Catenin expression exhibit the poorest overall survival. These collective insights underline the clinical importance of evaluating UBB, UBC, and β-Catenin as combined prognostic markers in PC.
前列腺癌（PC）是全球范围内一项重大的公共卫生问题，对男性健康构成显著负担，其发病率位居恶性肿瘤第二位。本研究深入探讨了泛素化过程与表达调控的复杂机制，特别聚焦于泛素B（UBB）、泛素C（UBC）及β-连环蛋白在PC发生发展中的作用。我们系统分析了UBB、UBC和β-连环蛋白的表达谱，探究它们之间的相互作用及其与临床病理学数据的关联。这些发现为揭示其作为可靠预后标志物的潜力及其对患者生存的重要意义提供了宝贵见解。我们的研究揭示了PC组织中UBB和UBC表达的上调现象，且在淋巴结转移灶中表达更为显著，凸显了它们在PC进展中的关键作用。此外，我们发现PC患者中高表达的UBB和UBC水平与较低的总生存率存在显著相关性，进一步强调了其临床意义。同时，我们观察到PC组织中膜性β-连环蛋白表达显著降低。值得注意的是，β-连环蛋白的异常表达与PC患者较短的生存期密切相关，并可作为患者预后的重要独立预后因素。Kaplan-Meier生存分析表明，同时具有UBB高表达和β-连环蛋白异常表达的肿瘤患者总生存期最差。这些综合发现凸显了评估UBB、UBC和β-连环蛋白作为PC联合预后标志物的临床价值。
肿瘤(癌症)患者之家