文章：

核内微小RNA、长链非编码RNA及环状RNA与PRC2及FUS结合在癌症中的意义

Implications in Cancer of Nuclear Micro RNAs, Long Non-Coding RNAs, and Circular RNAs Bound by PRC2 and FUS

原文发布日期：21 February 2024

DOI: 10.3390/cancers16050868

类型: Article

开放获取: 是

英文摘要：

The eukaryotic genome is mainly transcribed into non-coding RNAs (ncRNAs), including different RNA biotypes, such as micro RNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), among others. Although miRNAs are assumed to act primarily in the cytosol, mature miRNAs have been reported and functionally characterized in the nuclei of different cells. Further, lncRNAs are important regulators of different biological processes in the cell nucleus as part of different ribonucleoprotein complexes. CircRNAs constitute a relatively less-characterized RNA biotype that has a circular structure as result of a back-splicing process. However, circRNAs have recently attracted attention in different scientific fields due to their involvement in various biological processes and pathologies. In this review, we will summarize recent studies that link to cancer miRNAs that have been functionally characterized in the cell nucleus, as well as lncRNAs and circRNAs that are bound by core components of the polycomb repressive complex 2 (PRC2) or the protein fused in sarcoma (FUS), highlighting mechanistic aspects and their diagnostic and therapeutic potential.

摘要翻译： 

真核生物基因组主要转录为非编码RNA（ncRNAs），包含多种RNA生物型，如微小RNA（miRNAs）、长链非编码RNA（lncRNAs）和环状RNA（circRNAs）等。尽管miRNAs通常被认为主要在细胞质中发挥作用，但已有研究报道在不同细胞的细胞核中存在成熟miRNAs并对其功能进行了表征。此外，lncRNAs作为多种核糖核蛋白复合物的组成部分，在细胞核内调控多种生物学过程中发挥重要作用。CircRNAs作为一种相对研究较少的RNA生物型，其环状结构源于反向剪接过程。然而，由于circRNAs参与多种生物学过程及病理机制，近年来已在不同科学领域引起广泛关注。本综述将总结近期关于在细胞核内具有功能特征的癌症相关miRNAs的研究，以及被多梳抑制复合物2（PRC2）核心组分或肉瘤融合蛋白（FUS）结合的lncRNAs与circRNAs的研究进展，重点阐述其作用机制及其在诊断与治疗方面的潜在价值。

原文链接：

Implications in Cancer of Nuclear Micro RNAs, Long Non-Coding RNAs, and Circular RNAs Bound by PRC2 and FUS