Introduction: This study aimed to assess longitudinal associations between lifestyle and subsequent malignant neoplasms (SMNs) in young adult childhood cancer survivors. Methods: Members of the St. Jude Lifetime Cohort (SJLIFE) aged ≥18 years and surviving ≥5 years after childhood cancer diagnosis were queried and evaluated for physical activity, cardiorespiratory fitness (CRF), muscle strength, body mass index (BMI), smoking, risky drinking, and a combined lifestyle score. Time to first SMN, excluding nonmalignant neoplasms and nonmelanoma skin cancer, was the outcome of longitudinal analysis. Results: Survivors (n= 4072, 47% female, 29% smokers, 37% risky drinkers, 34% obese, and 48% physically inactive) had a mean (SD) time between baseline evaluation and follow-up of 7.0 (3.3) years, an age of 8.7 (5.7) years at diagnosis, and an age of 30 (8.4) years at baseline lifestyle assessment. Neither individual lifestyle factors nor a healthy lifestyle score (RR 0.8, 0.4–1.3,p= 0.36) were associated with the risk of developing an SMN. Conclusions: We did not identify any association between lifestyle factors and the risk of SMN in young adult childhood cancer survivors.
引言：本研究旨在评估青少年儿童癌症幸存者的生活方式与后续恶性新生物（SMNs）之间的纵向关联。方法：对圣裘德终身队列（SJLIFE）中年龄≥18岁、儿童期癌症确诊后存活≥5年的成员进行调查评估，内容包括体力活动、心肺适能（CRF）、肌肉力量、体重指数（BMI）、吸烟、危险饮酒及综合生活方式评分。纵向分析以首次发生SMN（排除非恶性新生物和非黑色素瘤皮肤癌）的时间为观察终点。结果：4072名幸存者（女性占47%，吸烟者29%，危险饮酒者37%，肥胖者34%，体力活动不足者48%）从基线评估至随访的平均（标准差）时间为7.0（3.3）年，确诊时平均年龄8.7（5.7）岁，基线生活方式评估时平均年龄30（8.4）岁。无论是单一生活方式因素还是健康生活方式综合评分（风险比0.8，95%置信区间0.4–1.3，p=0.36），均未发现与SMN发生风险存在显著关联。结论：在青少年儿童癌症幸存者群体中，我们未发现生活方式因素与SMN风险之间存在任何关联。
肿瘤(癌症)患者之家