文章：

细胞周期蛋白与细胞骨架蛋白在子宫内膜异位症中的作用：病理生理学机制解析

Role of Cyclins and Cytoskeletal Proteins in Endometriosis: Insights into Pathophysiology

原文发布日期：19 February 2024

DOI: 10.3390/cancers16040836

类型: Article

开放获取: 是

英文摘要：

Endometriosis is a gynecological condition where endometrium-like tissue grows outside the uterus, posing challenges in understanding and treatment. This article delves into the deep cellular and molecular processes underlying endometriosis, with a focus on the crucial roles played by cyclins and cytoskeletal proteins in its pathogenesis, particularly in the context of Epithelial–Mesenchymal Transition (EMT). The investigation begins by examining the activities of cyclins, elucidating their diverse biological roles such as cell cycle control, proliferation, evasion of apoptosis, and angiogenesis among ectopic endometrial cells. A comprehensive analysis of cytoskeletal proteins follows, emphasizing their fundamental biological roles and their specific significance to endometriotic cell features. This review sheds light on the interconnected pathways through which cyclins and cytoskeletal proteins converge, contributing to the genesis and progression of endometriosis. Understanding these molecular complexities not only provides insight into the underlying causes of the disease but also holds promise for the development of specific therapeutic approaches, ushering in a new era in the management of this devastating disorder.

摘要翻译： 

子宫内膜异位症是一种妇科疾病，其特征为子宫内膜样组织在子宫外生长，这给疾病的理解与治疗带来了挑战。本文深入探讨了子宫内膜异位症背后的深层细胞与分子过程，重点关注细胞周期蛋白和细胞骨架蛋白在其发病机制中的关键作用，特别是在上皮-间质转化（EMT）的背景下。研究首先审视了细胞周期蛋白的活性，阐明了其在异位子宫内膜细胞中多样的生物学作用，如细胞周期调控、增殖、凋亡逃逸以及血管生成。随后对细胞骨架蛋白进行了全面分析，强调了其基本的生物学功能及其对子宫内膜异位症细胞特性的特定意义。本综述揭示了细胞周期蛋白与细胞骨架蛋白相互关联、共同作用的通路，这些通路促进了子宫内膜异位症的发生与发展。理解这些分子层面的复杂性，不仅有助于洞察该疾病的根本原因，也为开发特异性治疗方法带来了希望，预示着这一棘手疾病的管理将进入一个新时代。

原文链接：

Role of Cyclins and Cytoskeletal Proteins in Endometriosis: Insights into Pathophysiology