Gliomas, the most prevalent primary malignant brain tumors, present a challenging prognosis even after undergoing surgery, radiation, and chemotherapy. Exosomes, nano-sized extracellular vesicles secreted by various cells, play a pivotal role in glioma progression and contribute to resistance against chemotherapy and radiotherapy by facilitating the transportation of biological molecules and promoting intercellular communication within the tumor microenvironment. Moreover, exosomes exhibit the remarkable ability to traverse the blood–brain barrier, positioning them as potent carriers for therapeutic delivery. These attributes hold promise for enhancing glioma diagnosis, prognosis, and treatment. Recent years have witnessed significant advancements in exosome research within the realm of tumors. In this article, we primarily focus on elucidating the role of exosomes in glioma development, highlighting the latest breakthroughs in therapeutic and diagnostic approaches, and outlining prospective directions for future research.
胶质瘤作为最常见的原发性恶性脑肿瘤，即使经过手术、放疗和化疗，其预后仍极具挑战性。外泌体是由多种细胞分泌的纳米级细胞外囊泡，在胶质瘤进展中发挥关键作用，通过促进生物分子的运输和增强肿瘤微环境内的细胞间通讯，导致化疗和放疗耐药。此外，外泌体具有跨越血脑屏障的卓越能力，使其成为极具潜力的治疗递送载体。这些特性为改善胶质瘤的诊断、预后评估和治疗提供了新希望。近年来，肿瘤领域的外泌体研究取得了显著进展。本文重点阐述外泌体在胶质瘤发展中的作用，介绍治疗与诊断方法的最新突破，并展望未来研究方向。
Exosomes in Glioma: Unraveling Their Roles in Progression, Diagnosis, and Therapy
肿瘤(癌症)患者之家