文章：

循环肿瘤细胞：挖掘这些转移种子的研究进展如何？

Circulating Tumor Cells: How Far Have We Come with Mining These Seeds of Metastasis?

原文发布日期：17 February 2024

DOI: 10.3390/cancers16040816

类型: Article

开放获取: 是

英文摘要：

Circulating tumor cells (CTCs) are cancer cells that slough off from the tumor and circulate in the peripheral blood and lymphatic system as micro metastases that eventually results in macro metastases. Through a simple blood draw, sensitive CTC detection from clinical samples has proven to be a useful tool for determining the prognosis of cancer. Recent technological developments now make it possible to detect CTCs reliably and repeatedly from a simple and straightforward blood test. Multicenter trials to assess the clinical value of CTCs have demonstrated the prognostic value of these cancer cells. Studies on CTCs have filled huge knowledge gap in understanding the process of metastasis since their identification in the late 19th century. However, these rare cancer cells have not been regularly used to tailor precision medicine and or identify novel druggable targets. In this review, we have attempted to summarize the milestones of CTC-based research from the time of identification to molecular characterization. Additionally, the need for a paradigm shift in dissecting these seeds of metastasis and the possible future avenues to improve CTC-based discoveries are also discussed.

摘要翻译： 

循环肿瘤细胞（CTCs）是从肿瘤脱落并进入外周血及淋巴系统循环的癌细胞，它们作为微转移灶最终导致宏观转移的发生。通过简单的血液采集，从临床样本中灵敏检测CTCs已被证实是评估癌症预后的有效工具。随着近期技术发展，如今已能通过简便直接的血液检测实现可靠且可重复的CTC检测。多项评估CTC临床价值的多中心试验已证实这些癌细胞的预后价值。自19世纪末被发现以来，CTC研究极大填补了人类对转移过程认知的知识空白。然而，这些稀有癌细胞尚未被常规应用于指导精准医疗或识别新型药物靶点。本综述系统梳理了从CTC发现到分子特征解析的研究里程碑，同时探讨了剖析这些"转移种子"所需的研究范式转变，以及未来提升CTC相关发现的潜在路径。

原文链接：

Circulating Tumor Cells: How Far Have We Come with Mining These Seeds of Metastasis?