文章：

骨髓增生异常综合征患者的感染并发症：杜塞尔多夫MDS登记处报告

Infectious Complications in Patients with Myelodysplastic Syndromes: A Report from the Düsseldorf MDS Registry

原文发布日期：16 February 2024

DOI: 10.3390/cancers16040808

类型: Article

开放获取: 是

英文摘要：

Despite notable advancements in infection prevention and treatment, individuals with hematologic malignancies still face the persistent threat of frequent and life-threatening complications. Those undergoing chemotherapy or other disease-modifying therapies are particularly vulnerable to developing infectious complications, increasing the risk of mortality. Myelodysplastic syndromes (MDS) predominantly affect the elderly, with the incidence rising with age and peaking at around 70 years. Patients with MDS commonly present with unexplained low blood-cell counts, primarily anemia, and often experience varying degrees of neutropenia as the disease progresses. In our subsequent retrospective study involving 1593 patients from the Düsseldorf MDS Registry, we aimed at outlining the incidence of infections in MDS patients and identifying factors contributing to heightened susceptibility to infectious complications in this population.

摘要翻译： 

尽管在感染预防与治疗方面取得了显著进展，血液系统恶性肿瘤患者仍面临频繁且危及生命的并发症的持续威胁。接受化疗或其他疾病修饰治疗的患者尤其容易发生感染性并发症，从而增加死亡风险。骨髓增生异常综合征（MDS）主要影响老年人群，其发病率随年龄增长而上升，在70岁左右达到高峰。MDS患者通常表现为不明原因的血细胞计数偏低（以贫血为主），且随着疾病进展常出现不同程度的中性粒细胞减少。在我们后续对杜塞尔多夫MDS登记处1593名患者开展的回顾性研究中，旨在阐明MDS患者的感染发生率，并确定导致该人群感染并发症易感性增加的相关因素。

原文链接：

Infectious Complications in Patients with Myelodysplastic Syndromes: A Report from the Düsseldorf MDS Registry