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文章:

离体乳腺组织的介电特性:通过介电常数测量区分肿瘤类型

Dielectric Characterization of Ex-Vivo Breast Tissues: Differentiation of Tumor Types through Permittivity Measurements

原文发布日期:15 February 2024

DOI: 10.3390/cancers16040793

类型: Article

开放获取: 是

 

英文摘要:

Early analysis and diagnosis of breast tumors is essential for either quickly launching a treatment or for seeing the evolution of patients who, for instance, have already undergone chemotherapy treatment. Once tissues are excised, histological analysis is the most frequent tool used to characterize benign or malignant tumors. Dielectric microwave spectroscopy makes use of an open-ended coaxial probe in the 1–8 GHz frequency range to quickly identify the type of tumor (ductal carcinoma, lobular carcinoma, mucinous carcinoma and fibroadenoma). The experiment was undertaken with data from 70 patients who had already undergone chemotherapy treatment, which helped to electrically map the histological tissues with their electric permittivity. Thus, the variations in the permittivity of different types of tumors reveal distinctive patterns: benign tumors have permittivity values lower than 35, while malignant ones range between 40 and 60. For example, at a frequency of 2 GHz, the measured permittivity was 45.6 for ductal carcinoma, 33.1 for lobular carcinoma, 59.5 for mucinous carcinoma, and 27.6 for benign tumors. This differentiation remains consistent in a frequency range of 1 to 4.5 GHz. These results highlight the effectiveness of these measurements in the classification of breast tumors, providing a valuable tool for quick and accurate diagnosis and effective treatment.

 

摘要翻译: 

乳腺肿瘤的早期分析与诊断对于快速启动治疗或监测患者病情演变(例如已接受化疗的患者)至关重要。组织切除后,组织学分析是鉴别良恶性肿瘤最常用的方法。介电微波光谱技术采用1-8GHz频段的开口同轴探头,可快速识别肿瘤类型(导管癌、小叶癌、黏液癌和纤维腺瘤)。本研究基于70例已接受化疗患者的实验数据,通过测量组织介电常数构建了电学特性图谱。实验结果表明:不同类型肿瘤的介电常数呈现显著差异——良性肿瘤介电常数低于35,恶性肿瘤介电常数介于40-60之间。例如在2GHz频率下,导管癌介电常数为45.6,小叶癌为33.1,黏液癌为59.5,良性肿瘤为27.6。这种差异在1-4.5GHz频段内保持稳定。研究结果证实了该测量方法在乳腺肿瘤分类中的有效性,为快速精准诊断和有效治疗提供了重要技术手段。

 

原文链接:

Dielectric Characterization of Ex-Vivo Breast Tissues: Differentiation of Tumor Types through Permittivity Measurements

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