One of the characteristic features of ovarian cancer is its early dissemination. Metastasis and the invasiveness of ovarian cancer are strongly dependent on the phenotypical and molecular determinants of cancer cells. Invasive cancer cells, circulating tumor cells, and cancer stem cells, which are responsible for the metastatic process, may all undergo different modes of transition, giving rise to mesenchymal, amoeboid, and redifferentiated epithelial cells. Such variability is the result of the changing needs of cancer cells, which strive to survive and colonize new organs. This would not be possible if not for the variety of migration modes adopted by the transformed cells. The most common type of metastasis in ovarian cancer is dissemination through the transcoelomic route, but transitions in ovarian cancer cells contribute greatly to hematogenous and lymphatic dissemination. This review aims to outline the transition modes of ovarian cancer cells and discuss the migratory capabilities of those cells in light of the known ovarian cancer metastasis routes.
卵巢癌的特征之一是其早期播散。卵巢癌的转移和侵袭性在很大程度上取决于癌细胞的表型和分子决定因素。参与转移过程的侵袭性癌细胞、循环肿瘤细胞和癌症干细胞可能经历不同的转化模式，从而产生间充质细胞、类变形虫细胞和再分化上皮细胞。这种变异性源于癌细胞为生存和定植新器官而不断变化的需求。若非转化细胞采用多种迁移模式，这一过程将无法实现。卵巢癌最常见的转移类型是通过经腹腔途径播散，但卵巢癌细胞的转化对血行和淋巴播散也起着重要作用。本综述旨在概述卵巢癌细胞的转化模式，并结合已知的卵巢癌转移途径探讨这些细胞的迁移能力。
A Recipe for Successful Metastasis: Transition and Migratory Modes of Ovarian Cancer Cells
肿瘤(癌症)患者之家