The gut microbiota composition can affect the tumor microenvironment and its interaction with the immune system, thereby having implications for treatment predictions. This article reviews the studies available to better understand how the gut microbiome helps the immune system fight cancer. To describe this fact, different mechanisms and approaches utilizing probiotics to improve advancements in cancer treatment will be discussed. Moreover, not only calorie intake but also the variety and quality of diet can influence cancer patients’ immunotherapy treatment because dietary patterns can impair immunological activities either by stimulating or suppressing innate and adaptive immunity. Therefore, it is interesting and critical to understand gut microbiome composition as a biomarker to predict cancer immunotherapy outcomes and responses. Here, more emphasis will be given to the recent development in immunotherapies utilizing microbiota to improve cancer therapies, which is beneficial for cancer patients.
肠道菌群组成可影响肿瘤微环境及其与免疫系统的相互作用，进而对治疗预测产生影响。本文综述现有研究，以深入理解肠道微生物组如何协助免疫系统对抗癌症。为阐明这一机制，将探讨利用益生菌改善癌症治疗进展的不同作用途径与方法。值得注意的是，不仅热量摄入，饮食的多样性与质量同样会影响癌症患者的免疫治疗效果，因为膳食模式可通过刺激或抑制先天性与适应性免疫来影响免疫活性。因此，将肠道微生物组构成作为预测癌症免疫治疗结果与反应的生物标志物具有重要研究价值。本文将重点阐述利用微生物组改善癌症治疗的最新免疫治疗进展，这对癌症患者具有积极意义。
The Microbiome Modulates the Immune System to Influence Cancer Therapy
肿瘤(癌症)患者之家