文章：

雄激素受体信号通路在尿路上皮癌中的作用

Roles of Androgen Receptor Signaling in Urothelial Carcinoma

原文发布日期：10 February 2024

DOI: 10.3390/cancers16040746

类型: Article

开放获取: 是

英文摘要：

Preclinical and clinical data suggest that androgen receptor signaling strongly contributes to bladder cancer development. The roles of the androgen receptor in bladder carcinogenesis have obvious implications for understanding the strong male sex bias in this disease and for potential therapeutic strategies as well. In this review, we summarize what is known about androgen receptor signaling in urothelial carcinoma as well as in tumor-infiltrating immune cells, reviewing preclinical and clinical data. We also highlight clinical trial efforts in this area.

摘要翻译： 

临床前及临床数据表明，雄激素受体信号通路在膀胱癌发生发展中起关键作用。雄激素受体在膀胱癌发生机制中的作用，不仅有助于解释该疾病显著的男性性别倾向性，也为潜在治疗策略提供了理论依据。本综述系统梳理了尿路上皮癌及肿瘤浸润免疫细胞中雄激素受体信号通路的研究进展，整合分析了临床前与临床研究数据，并对该领域的临床试验成果进行了重点评述。

原文链接：

Roles of Androgen Receptor Signaling in Urothelial Carcinoma