This research investigated the serum levels of three interleukins (IL8, IL17A, and IL33) and the possible relationships between them in healthy people and colon cancer patients at different stages. This study involved 82 participants, 42 of whom had colon cancer and 40 were healthy individuals. The cancer patients were classified into four groups according to the TNM staging classification of colon and rectal cancer. Serum levels of the interleukins were measured by the ELISA test. The data were analyzed statistically to compare the demographic characteristics, the interleukin levels across cancer stages, and the correlation between interleukins in both groups. The results showed that women had more early-stage colon cancer diagnoses, while men had more advanced-stage cancer diagnoses. Stage two colon cancer was more common in older people. Younger people, men, and those with early-stage colon cancer had higher levels of interleukins. The levels of IL8 and IL17A were higher in the cancer group, while the level of IL33 was higher in the healthy group. There was a strong correlation between IL8 and IL17A levels in both groups (p= 0.001). IL17A influenced the level of IL33 in the cancer group (p= 0.007). This study suggested that cytokine variation profiles could be useful for detecting colon cancer and predicting its outcome.
本研究探讨了健康人群与不同分期结肠癌患者血清中三种白细胞介素（IL8、IL17A和IL33）的水平及其潜在关联。研究共纳入82名参与者，其中42名为结肠癌患者，40名为健康个体。癌症患者根据结直肠癌TNM分期标准分为四组。采用ELISA法检测血清白细胞介素水平，并通过统计学方法分析比较两组人群的人口学特征、各癌症分期的白细胞介素水平以及白细胞介素间的相关性。结果显示：女性更易在早期被诊断为结肠癌，而男性晚期诊断比例更高；二期结肠癌在老年人群中更为常见；年轻人群、男性及早期结肠癌患者的白细胞介素水平较高。癌症组IL8和IL17A水平更高，而健康组IL33水平更高。两组中IL8与IL17A水平均呈强相关性（p=0.001）。在癌症组中，IL17A对IL33水平具有影响（p=0.007）。本研究表明，细胞因子变异谱可能有助于结肠癌的检测和预后预测。
Serum Interleukins 8, 17, and 33 as Potential Biomarkers of Colon Cancer
肿瘤(癌症)患者之家