文章：

肠道微生物组、环境及饮食对早发性结直肠癌发展的影响

The Impact of the Gut Microbiome, Environment, and Diet in Early-Onset Colorectal Cancer Development

原文发布日期：5 February 2024

DOI: 10.3390/cancers16030676

类型: Article

开放获取: 是

英文摘要：

Traditionally considered a disease common in the older population, colorectal cancer is increasing in incidence among younger demographics. Evidence suggests that populational- and generational-level shifts in the composition of the human gut microbiome may be tied to the recent trends in gastrointestinal carcinogenesis. This review provides an overview of current research and putative mechanisms behind the rising incidence of colorectal cancer in the younger population, with insight into future interventions that may prevent or reverse the rate of early-onset colorectal carcinoma.

摘要翻译： 

传统上被视为老年人群常见疾病的结直肠癌，在年轻群体中的发病率正持续上升。现有证据表明，人类肠道微生物群落在人口及代际层面的组成变化，可能与近期胃肠道癌变趋势存在关联。本综述系统梳理了当前关于年轻人群结直肠癌发病率上升的研究进展及其潜在机制，并对未来可能预防或逆转早发性结直肠癌发病率的干预策略进行了展望。

原文链接：

The Impact of the Gut Microbiome, Environment, and Diet in Early-Onset Colorectal Cancer Development