Background: Malnutrition was associated with worse survival outcomes, impaired quality of life, and deteriorated performance status across various cancer types. We aimed to identify risk factors for malnutrition in patients with epithelial ovarian cancer (EOC) and impact on survival. Methods: In our prospective observational monocentric study, we included the patients with primary and recurrent EOC, tubal or peritoneal cancer conducted. We assessed serum laboratory parameters, body mass index, nutritional risk index, nutritional risk screening score (NRS-2002), and bio-electrical impedance analysis. Results: We recruited a total of 152 patients. Patients > 65 years-old, with ascites of >500 mL, or with platinum-resistant EOC showed statistically significant increased risk of malnutrition when evaluated using NRS-2002 (p-values= 0.014, 0.001, and 0.007, respectively). NRS-2002 < 3 was an independent predictive factor for complete tumor resectability (p= 0.009). The patients with NRS-2002 ≥ 3 had a median overall survival (OS) of seven months (95% CI = 0–24 months), as compared to the patients with NRS-2002 < 3, where median OS was forty-six months (p= 0.001). A phase angle (PhAα) ≤ 4.5 was the strongest predictor of OS. Conclusions: In our study, we found malnutrition to be an independent predictor of incomplete cytoreduction and independent prognostic factor for poor OS. Preoperative nutritional assessment is an effective tool in the identification of high-risk EOC groups characterized by poor clinical outcome.
背景：营养不良与多种癌症患者较差的生存结局、生活质量下降及体能状态恶化相关。本研究旨在明确上皮性卵巢癌（EOC）患者营养不良的危险因素及其对生存的影响。方法：在这项前瞻性观察性单中心研究中，我们纳入了原发性和复发性EOC、输卵管癌或腹膜癌患者。评估指标包括血清实验室参数、体重指数、营养风险指数、营养风险筛查评分（NRS-2002）及生物电阻抗分析。结果：共纳入152例患者。通过NRS-2002评估发现，年龄>65岁、腹水量>500 mL或铂类耐药EOC患者营养不良风险显著增加（p值分别为0.014、0.001和0.007）。NRS-2002<3是肿瘤完全切除的独立预测因素（p=0.009）。NRS-2002≥3患者的中位总生存期（OS）为7个月（95% CI=0-24个月），而NRS-2002<3患者的中位OS为46个月（p=0.001）。相位角（PhAα）≤4.5是OS最强的预测因子。结论：本研究发现营养不良是肿瘤不完全减灭术的独立预测因子，也是不良OS的独立预后因素。术前营养评估是识别临床结局较差的高危EOC群体的有效工具。
肿瘤(癌症)患者之家