The present study focuses on the development of a methodology for evaluating the safety of MNH systems, through the numerical prediction of the induced temperature rise in superficial skin layers due to eddy currents heating under an alternating magnetic field (AMF). The methodology is supported and validated through experimental measurements of the AMF’s distribution, as well as temperature data from the torsos of six patients who participated in a clinical trial study. The simulations involved a computational model of the actual coil, a computational model of the cooling system used for the cooling of the patients during treatment, and a detailed human anatomical model from the Virtual Population family. The numerical predictions exhibit strong agreement with the experimental measurements, and the deviations are below the estimated combined uncertainties, confirming the accuracy of computational modeling. This study highlights the crucial role of simulations for translational medicine and paves the way for personalized treatment planning.
本研究致力于开发一种评估磁纳米热疗系统安全性的方法，该方法通过数值模拟预测交变磁场下涡流效应对皮肤表层产生的温升。该方法的有效性通过交变磁场分布实验测量数据以及六名临床试验患者躯干部位的温度数据得到验证与支持。模拟过程包含实际线圈计算模型、治疗过程中患者冷却系统的计算模型，以及基于虚拟人群数据库的精细化人体解剖模型。数值预测结果与实验测量数据高度吻合，偏差低于预估综合不确定度，证实了计算建模的准确性。本研究凸显了数值模拟在转化医学中的关键作用，并为个性化治疗方案的制定开辟了新路径。
肿瘤(癌症)患者之家