文章：

角化细胞性皮肤癌流行病学：聚焦于皮肤鳞状细胞癌

Epidemiology of Keratinocyte Skin Cancer with a Focus on Cutaneous Squamous Cell Carcinoma

原文发布日期：31 January 2024

DOI: 10.3390/cancers16030606

类型: Article

开放获取: 是

英文摘要：

Keratinocyte skin cancer, consisting of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), is by far the most common cancer in white-skinned populations, with rapid increases over the last 50 years. While the age-standardized incidence rates increase worldwide, the age-standardized mortality rates are variable. The incidence rates of keratinocyte skin cancer are much higher compared to those of melanoma, and are largely attributed to the raising exposure to ultraviolet (UV) radiation, the most important causal risk factor for skin cancer. Whereas the development of BCC is mainly due to intense UV exposure during childhood and adolescence, the development of SCC is related to chronic, cumulative UV exposure over decades. Although mortality rates are relatively low, SCC is an increasing problem for healthcare services, significantly causing morbidity, especially in older age groups. This review reports on the epidemiology of keratinocyte skin cancer, with a focus on SCC, in Australia, the United States, and the north of Europe, with an outlook on further challenges health systems will be confronted with in the next 20 years.

摘要翻译： 

角质形成细胞皮肤癌，包括基底细胞癌（BCC）和鳞状细胞癌（SCC），是迄今为止白肤色人群中最常见的癌症，过去50年间发病率迅速增长。尽管全球范围内的年龄标准化发病率持续上升，但年龄标准化死亡率却存在差异。与黑色素瘤相比，角质形成细胞皮肤癌的发病率显著更高，这主要归因于紫外线（UV）辐射暴露的增加，而紫外线是皮肤癌最重要的致病风险因素。基底细胞癌的发生主要与儿童期和青春期的强烈紫外线暴露有关，而鳞状细胞癌的发展则与数十年来长期、累积的紫外线暴露相关。尽管死亡率相对较低，但鳞状细胞癌对医疗服务体系构成了日益严峻的挑战，尤其在老年群体中显著导致发病率上升。本综述报告了澳大利亚、美国和北欧地区角质形成细胞皮肤癌（重点关注鳞状细胞癌）的流行病学特征，并对未来20年卫生系统将面临的新挑战进行了展望。

原文链接：

Epidemiology of Keratinocyte Skin Cancer with a Focus on Cutaneous Squamous Cell Carcinoma