Little is known about how health-related quality of life (HRQoL) in breast cancer cases differed from that of controls during and after the COVID-19 pandemic. This study used data from an ongoing, nationwide HRQoL survey of 4279 newly diagnosed breast cancer cases and 2911 controls to investigate how breast cancer patients fared during different phases of the pandemic compared to controls. Responders during 2020–2022 were categorized into three COVID-19-related phases: the social restrictions phase, the high infection rate phase, and the post-pandemic phase. Across phases, breast cancer cases had significantly worse scores in most HRQoL domains compared to controls. Apart from slightly more insomnia in the high infection rate phase for both cases and controls, and better social functioning for young cases in the post-COVID-19 phase, the case-control differences in HRQoL remained consistent across phases. When the phases were assessed as one period, young women and those living with children <18 years of age fared the worst among breast cancer cases, while single women fared the worst among controls. In contrast, controls living with children <18 years of age exhibited better HRQoL than controls without children. In summary, women with breast cancer did not appear to fare differently than controls in terms of HRQoL across COVID-19 phases. However, breast cancer cases with young children fared worse in their HRQoL than other breast cancer cases.
关于乳腺癌患者在COVID-19大流行期间及之后与对照组在健康相关生活质量（HRQoL）方面的差异，目前知之甚少。本研究利用一项全国性HRQoL调查数据，对4279例新诊断乳腺癌患者及2911例对照组进行分析，探讨乳腺癌患者在大流行不同阶段与对照组相比的生活质量状况。2020-2022年受访者被划分为三个疫情相关阶段：社会限制阶段、高感染率阶段及大流行后阶段。在所有阶段中，乳腺癌患者在大多数HRQoL领域的评分均显著低于对照组。除高感染率阶段患者与对照组均出现轻微失眠增多，以及大流行后阶段年轻患者社会功能较好外，各阶段HRQoL的病例-对照组差异保持稳定。当将各阶段合并评估时，年轻女性及与18岁以下子女同住的乳腺癌患者生活质量最差，而单身女性在对照组中生活质量最低。值得注意的是，与无子女对照组相比，有18岁以下子女的对照组表现出更好的HRQoL。总体而言，乳腺癌患者在各疫情阶段的HRQoL与对照组未见显著差异，但育有幼童的乳腺癌患者HRQoL明显低于其他乳腺癌患者。
肿瘤(癌症)患者之家