Given the heterogeneity of different malignant processes, planning cancer treatment is challenging. According to recent studies, natural products are likely to be effective in cancer prevention and treatment. Among bioactive flavonoids found in fruits and vegetables, kaempferol (KMP) is known for its anti-inflammatory, antioxidant, and anticancer properties. This systematic review aims to highlight the potential therapeutic effects of KMP on different types of solid malignant tumors. This review was conducted following the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. Searches were performed in EMBASE, Medline/PubMed, Cochrane Collaboration Library, Science Direct, Scopus, and Google Scholar. After the application of study criteria, 64 studies were included. In vitro experiments demonstrated that KMP exerts antitumor effects by controlling tumor cell cycle progression, proliferation, apoptosis, migration, and invasion, as well as by inhibiting angiogenesis. KMP was also able to inhibit important markers that regulate epithelial–mesenchymal transition and enhanced the sensitivity of cancer cells to traditional drugs used in chemotherapy, including cisplatin and 5-fluorouracil. This flavonoid is a promising therapeutic compound and its combination with current anticancer agents, including targeted drugs, may potentially produce more effective and predictable results.
鉴于不同恶性病变的异质性，癌症治疗方案的制定具有挑战性。近期研究表明，天然产物在癌症预防与治疗中可能具有显著效果。在果蔬中发现的生物活性黄酮类化合物中，山奈酚以其抗炎、抗氧化及抗癌特性而备受关注。本系统综述旨在阐明山奈酚对各类实体恶性肿瘤的潜在治疗作用。研究严格遵循系统综述与荟萃分析优先报告条目指南，通过检索EMBASE、Medline/PubMed、Cochrane协作网图书馆、Science Direct、Scopus及Google Scholar数据库，依据纳入标准最终收录64项研究。体外实验表明，山奈酚通过调控肿瘤细胞周期进程、增殖、凋亡、迁移与侵袭，以及抑制血管生成等机制发挥抗肿瘤作用。该化合物还能抑制调控上皮-间质转化的关键标志物，并增强癌细胞对顺铂、5-氟尿嘧啶等传统化疗药物的敏感性。山奈酚作为一种前景广阔的治疗性化合物，与现有抗癌药物（包括靶向药物）联用可能产生更显著且可预测的协同疗效。
The Anticancer Potential of Kaempferol: A Systematic Review Based on In Vitro Studies
肿瘤(癌症)患者之家