文章：

G蛋白偶联受体与离子通道在顺铂诱导的周围神经病变中的作用：临床前研究综述

G Protein-Coupled Receptors and Ion Channels Involvement in Cisplatin-Induced Peripheral Neuropathy: A Review of Preclinical Studies

原文发布日期：30 January 2024

DOI: 10.3390/cancers16030580

类型: Article

开放获取: 是

英文摘要：

Cisplatin is a platinum-based chemotherapy drug widely used to treat various solid tumours. Although it is effective in anti-cancer therapy, many patients develop peripheral neuropathy during and after cisplatin treatment. Peripheral neuropathy results from lesions or diseases in the peripheral somatosensory nervous system and is a significant cause of debilitation and suffering in patients. In recent years, preclinical studies have been conducted to elucidate the mechanisms involved in chemotherapy-induced peripheral neuropathic pain, as well as to promote new therapeutic targets since current treatments are ineffective and are associated with adverse effects. G-protein coupled receptors and ion channels play a significant role in pain processing and may represent promising targets for improving the management of cisplatin-induced neuropathic pain. This review describes the role of G protein-coupled receptors and ion channels in cisplatin-induced pain, analysing preclinical experimental studies that investigated the role of each receptor subtype in the modulation of cisplatin-induced pain.

摘要翻译： 

顺铂是一种广泛用于治疗多种实体瘤的铂类化疗药物。尽管其在抗癌治疗中效果显著，但许多患者在顺铂治疗期间及治疗后会出现周围神经病变。周围神经病变源于周围躯体感觉神经系统的损伤或疾病，是导致患者功能衰退和痛苦的重要原因。近年来，临床前研究致力于阐明化疗诱导的周围神经病理性疼痛机制，并探索新的治疗靶点，因为现有治疗方法效果有限且常伴随不良反应。G蛋白偶联受体和离子通道在疼痛信号传导中发挥重要作用，可能成为改善顺铂诱导神经病理性疼痛管理的潜在靶点。本综述阐述了G蛋白偶联受体与离子通道在顺铂诱导疼痛中的作用，系统分析了探讨各受体亚型在调控顺铂诱导疼痛中功能的临床前实验研究。

原文链接：

G Protein-Coupled Receptors and Ion Channels Involvement in Cisplatin-Induced Peripheral Neuropathy: A Review of Preclinical Studies