Colorectal cancer (CRC) is the third most common neoplasia in the world. Its mortality rate is high due to the lack of specific and effective treatments, metastasis, and resistance to chemotherapy, among other factors. The natural products in cancer are a primary source of bioactive molecules. In this research, we evaluated the antitumor activity of an acetogenin (ACG), laherradurin (LH), isolated from the Mexican medicinal plantAnnona macroprophyllataDonn.Sm. in a CRC murine model. The CRC was induced by azoxymethane–dextran sulfate sodium (AOM/DSS) in Balb/c mice and treated for 21 days with LH or cisplatin. This study shows for the first time the antitumor activity of LH in an AOM/DSS CRC model. The acetogenin diminished the number and size of tumors compared with cisplatin; the histologic studies revealed a recovery of the colon tissue, and the blood toxicity data pointed to less damage in animals treated with LH. The TUNEL assay indicated cell death by apoptosis, and the in vitro studies exhibited that LH inhibited cell migration in HCT116 cells. Our study provides strong evidence of a possible anticancer agent for CRC.
结直肠癌是全球第三大常见肿瘤。由于缺乏特异性有效疗法、易发生转移及对化疗耐药等因素，该疾病死亡率居高不下。天然产物是癌症生物活性分子的重要来源。本研究评估了从墨西哥药用植物大叶番荔枝中分离出的番荔枝内酯类化合物laherradurin（LH）在结直肠癌小鼠模型中的抗肿瘤活性。通过氧化偶氮甲烷-葡聚糖硫酸钠（AOM/DSS）诱导Balb/c小鼠形成结直肠癌模型，并分别给予LH或顺铂治疗21天。本研究首次揭示了LH在AOM/DSS结直肠癌模型中的抗肿瘤作用：与顺铂相比，该番荔枝内酯能显著减少肿瘤数量并缩小瘤体体积；组织学分析显示结肠组织得到修复，血液毒性数据表明LH治疗组动物损伤更轻。TUNEL检测提示细胞通过凋亡途径死亡，体外实验证实LH能抑制HCT116细胞的迁移能力。本研究为结直肠癌潜在抗癌药物的开发提供了有力证据。
肿瘤(癌症)患者之家