Introduction: Changes in health-related quality of life (HRQoL) during the diagnostic and treatment trajectory of high-grade extremity soft-tissue sarcoma (eSTS) has rarely been investigated for adults (18–65 y) and the elderly (aged ≥65 y), despite a potential variation in challenges from diverse levels of physical, social, or work-related activities. This study assesses HRQoL from time of diagnosis to one year thereafter among adults and the elderly with eSTS. Methods: HRQoL of participants from the VALUE-PERSARC trial (n= 97) was assessed at diagnosis and 3, 6 and 12 months thereafter, utilizing the PROMIS Global Health (GH), PROMIS Physical Function (PF) and EQ-5D-5L. Results: Over time, similar patterns were observed in all HRQoL measures, i.e., lower HRQoL scores than the Dutch population at baseline (PROMIS-PF:46.8, PROMIS GH-Mental:47.3, GH-Physical:46.2, EQ-5D-5L:0.76, EQ-VAS:72.6), a decrease at 3 months, followed by an upward trend to reach similar scores as the general population at 12 months (PROMIS-PF:49.9, PROMIS GH-Physical:50.1, EQ-5D-5L:0.84, EQ-VAS:81.5), except for the PROMIS GH-Mental (47.5), where scores remained lower than the general population mean (T = 50). Except for the PROMIS-PF, no age-related differences were observed. Conclusions: On average, eSTS patients recover well physically from surgery, yet the mental component demonstrates no progression, irrespective of age. These results underscore the importance of comprehensive care addressing both physical and mental health.
引言：尽管不同年龄群体在身体、社交或工作活动方面面临的挑战可能存在差异，但针对成人（18-65岁）与老年（≥65岁）高级别肢体软组织肉瘤患者在诊断与治疗过程中的健康相关生命质量变化研究仍较为有限。本研究评估了肢体软组织肉瘤患者从确诊至一年后HRQoL的演变轨迹。方法：采用PROMIS整体健康量表、PROMIS躯体功能量表及EQ-5D-5L量表，对VALUE-PERSARC试验的97名参与者在确诊时及确诊后3、6、12个月进行HRQoL评估。结果：所有HRQoL指标随时间呈现相似变化规律：基线期评分均低于荷兰常模人群（PROMIS-PF:46.8，PROMIS GH心理维度:47.3，GH躯体维度:46.2，EQ-5D-5L:0.76，EQ-VAS:72.6），3个月时出现下降，随后呈上升趋势，至12个月时除PROMIS GH心理维度（47.5）仍低于常模均值（T=50）外，其余指标均恢复至普通人群水平（PROMIS-PF:49.9，PROMIS GH躯体维度:50.1，EQ-5D-5L:0.84，EQ-VAS:81.5）。除PROMIS-PF外，各指标均未观察到年龄相关差异。结论：肢体软组织肉瘤患者术后躯体功能普遍恢复良好，但心理维度未见明显改善，且该现象与年龄无关。这些结果凸显了在临床照护中同时关注患者身心健康的必要性。
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