Long non-coding RNAs’ HOTAIR rs920778, LINC00951 rs11752942, POLR2E rs3787016, and HULC rs7763881 are progressively reported having a close genetic affinity with esophageal carcinogenesis in the East. Nonetheless, their correlation with variables already endorsed as significant prognostic factors in terms of staging, guiding treatment and predicting recurrence, metastasis, and survival have yet to be explored. Herein, we investigated their prognostic value by correlating them with clinicopathological and laboratory prognostic markers in esophageal cancer in the West. Formalin-fixed paraffin-embedded tissue specimens from 95 consecutive patients operated on for esophageal cancer between 2014 and 2018 were compared with 121 healthy community controls. HULC was not detected differently in any of the cancer prognostic subgroups. LINC00951 was underrepresented in Ca19.9 elevated subgroup. HOTAIR was more frequent in both worse differentiation grade and positive Signet-Ring-Cell and Ca19.9 subgroups. POLR2E was identified less frequently in Adenocarcinoma, Signet-Ring-Cell, and Diffuse histologies, as well as in Perineural, Lymphovascular, and Perivascular Invasion positive, while it was overrepresented in CEA positive subgroup. These lncRNAs polymorphisms may hold great potential not only as future therapeutic agents but also as novel markers for predictive analysis of esophageal cancer risk, clinical outcome, and survival. Clinical implications of these findings need to be validated with prospective larger sample-size studies.
长链非编码RNA HOTAIR rs920778、LINC00951 rs11752942、POLR2E rs3787016和HULC rs7763881在东亚人群中被陆续报道与食管癌发生具有密切遗传关联。然而，这些位点与已被证实对分期、指导治疗及预测复发、转移和生存具有重要意义的预后因素之间的相关性尚未得到探索。本研究通过分析其与西方食管癌患者临床病理及实验室预后标志物的关联，评估了这些位点的预后价值。研究纳入2014年至2018年间连续接受手术治疗的95例食管癌患者的福尔马林固定石蜡包埋组织标本，并与121例健康社区对照进行比较。结果显示：HULC在各癌症预后亚组中均未呈现差异表达；LINC00951在CA19.9升高亚组中表达偏低；HOTAIR在低分化亚组、印戒细胞阳性亚组及CA19.9升高亚组中出现频率更高；POLR2E在腺癌、印戒细胞癌及弥漫型组织学亚型中检出率较低，在神经侵犯、淋巴血管侵犯及血管侵犯阳性亚组中表达减少，而在CEA阳性亚组中呈现过表达。这些lncRNA多态性不仅可能成为未来潜在的治疗靶点，更有望作为预测食管癌风险、临床转归及生存的新型标志物。这些发现的临床意义仍需通过前瞻性大样本研究进一步验证。
肿瘤(癌症)患者之家