A steady increase in the incidence and mortality burden correlated to thin melanomas (≤1 mm) has been reported in recent years in some international studies, but there is currently a paucity of data from the Mediterranean area. We aimed to describe the epidemiological characteristics of thin melanoma in Tuscany, Central Italy. A total of 6002 first cutaneous invasive melanomas occurring from 1985 to 2017 were selected for analysis; data were retrieved from the local population-based cancer registry. The standardized incidence rate was 15.0 per 100,000 in the population, higher among men than women (16.5 vs. 14.1). Incidence rates tended to increase over time across all age group-specific population strata, with annual percent changes moderately higher among men (+8.0%) than women (+6.9%), especially among the elderly. Among both sexes and in each age group, the trend toward increasing incidence rates was particularly strong for thin melanomas. Survival was better among women than men across all categories of thickness. Approximately 15% of deaths occurred among patients with thin lesions, with no major temporal changes in recent years. This study contributes to an improved understanding of melanoma epidemiology in Tuscany and underscores the need for primary prevention strategies tackling the growing burden of thin melanomas.
近年来部分国际研究报道，与薄型黑色素瘤（厚度≤1毫米）相关的发病率和死亡率负担呈稳定上升趋势，但目前地中海地区相关数据仍较为匮乏。本研究旨在描述意大利中部托斯卡纳地区薄型黑色素瘤的流行病学特征。我们选取了1985年至2017年间发生的6002例首次皮肤侵袭性黑色素瘤病例进行分析，数据来源于当地基于人口的癌症登记系统。标准化发病率为每10万人15.0例，男性发病率（16.5例）高于女性（14.1例）。各年龄层人群的发病率均随时间呈上升趋势，男性年度变化百分比（+8.0%）略高于女性（+6.9%），老年群体中这一差异尤为明显。在所有性别和年龄组中，薄型黑色素瘤的发病率增长趋势尤为显著。在不同厚度分组的患者中，女性生存率均优于男性。约15%的死亡病例发生在薄型病灶患者中，且近年来未出现显著的时间变化。本研究有助于深化对托斯卡纳地区黑色素瘤流行病学的认识，并强调需要制定针对薄型黑色素瘤日益增长负担的一级预防策略。
肿瘤(癌症)患者之家