The rising global incidence of uterine cancer is linked to the escalating prevalence of obesity. Obesity results in alterations in adipocytokines and IGFs, driving cancer progression via inflammation, increased cell proliferation, and apoptosis inhibition, although the precise mechanisms are still unclear. This study examined a set of six markers, namely, adiponectin, leptin, IL6, TNFα, IGF1, and IGF2 and compared them between fifty age-matched endometrial cancer patients (study group) and non-cancer patients with benign gynaecological conditions (control group). We also assessed the relationship of these markers with obesity and explored the correlation between these markers and various tumour characteristics. In the cancer population, these markers were also assessed 24 h and 6 months post-surgery. Remarkably, low adiponectin levels were associated with a 35.8% increase in endometrial cancer risk. Interestingly, compared to control subjects where IGF levels decreased after menopause, post-menopausal women in the study group showed elevated IGF1 and IGF2 levels, suggesting a potential influence of endometrial cancer on the IGF system, particularly after menopause. Lastly, it is noteworthy that a discernible inverse relationship trend was observed in the levels of adipocytokines and IGFs 6 months post-surgery. This indicates that treatment for endometrial cancer may have a differential impact on adipocytokines and IGFs, potentially holding clinical significance that merits further investigation.
全球子宫癌发病率的上升与肥胖患病率的增加有关。肥胖导致脂肪细胞因子和胰岛素样生长因子发生改变，通过炎症反应、细胞增殖增加和细胞凋亡抑制来驱动癌症进展，尽管其确切机制尚不明确。本研究检测了六种标志物，即脂联素、瘦素、白细胞介素6、肿瘤坏死因子α、胰岛素样生长因子1和胰岛素样生长因子2，并在50名年龄匹配的子宫内膜癌患者（研究组）与非癌症良性妇科疾病患者（对照组）之间进行了比较。我们还评估了这些标志物与肥胖的关系，并探讨了这些标志物与各种肿瘤特征之间的相关性。在癌症人群中，我们还评估了术后24小时和6个月时这些标志物的变化。值得注意的是，低脂联素水平与子宫内膜癌风险增加35.8%相关。有趣的是，与对照组绝经后胰岛素样生长因子水平下降相比，研究组绝经后女性显示出胰岛素样生长因子1和胰岛素样生长因子2水平升高，这表明子宫内膜癌可能对胰岛素样生长因子系统产生影响，尤其是在绝经后。最后，值得注意的是，术后6个月脂肪细胞因子和胰岛素样生长因子水平呈现出明显的反向关系趋势。这表明子宫内膜癌的治疗可能对脂肪细胞因子和胰岛素样生长因子产生不同的影响，可能具有临床意义，值得进一步研究。
肿瘤(癌症)患者之家