Obesity is a global health challenge with increasing prevalence, and its intricate relationship with cancer has become a critical concern in cancer care. As a result, understanding the multifactorial connections between obesity and breast cancer is imperative for risk stratification, tailored screening, and rehabilitation treatment planning to address long-term survivorship issues. The review follows the SANRA quality criteria and includes an extensive literature search conducted in PubMed/Medline, Web of Science, and Scopus. The biological basis linking obesity and cancer involves complex interactions in adipose tissue and the tumor microenvironment. Various mechanisms, such as hormonal alterations, chronic inflammation, immune system modulation, and mitochondrial dysfunction, contribute to cancer development. The review underlines the importance of comprehensive oncologic rehabilitation, including physical, psychological, and nutritional aspects. Cancer rehabilitation plays a crucial role in managing obesity-related symptoms, offering interventions for physical impairments, pain management, and lymphatic disorders, and improving both physical and psychological well-being. Personalized and technology-driven approaches hold promise for optimizing rehabilitation effectiveness and improving long-term outcomes for obese cancer patients. The comprehensive insights provided in this review contribute to the evolving landscape of cancer care, emphasizing the importance of tailored rehabilitation in optimizing the well-being of obese cancer patients.
肥胖已成为全球性健康挑战，其患病率持续上升，与癌症之间的复杂关联已成为肿瘤治疗领域的关键议题。因此，深入理解肥胖与乳腺癌之间的多因素联系，对于风险分层、个体化筛查以及解决长期生存问题的康复治疗规划至关重要。本综述遵循SANRA质量标准，通过PubMed/Medline、Web of Science和Scopus数据库进行了系统性文献检索。肥胖与癌症关联的生物学基础涉及脂肪组织与肿瘤微环境间的复杂相互作用，激素水平改变、慢性炎症、免疫系统调节及线粒体功能障碍等多种机制共同促进了癌症发展。综述强调综合肿瘤康复的重要性，涵盖生理、心理及营养多维度干预。肿瘤康复在管理肥胖相关症状、实施功能障碍干预、疼痛管理与淋巴系统疾病治疗方面发挥关键作用，有效提升患者身心福祉。个体化与科技驱动的康复策略有望优化肥胖癌症患者的康复效果，改善长期预后。本综述提供的全面见解有助于推动肿瘤治疗领域发展，突显个体化康复对优化肥胖癌症患者健康状况的重要意义。
肿瘤(癌症)患者之家