文章：

PEDF在癌症中的多重作用

The Various Roles of PEDF in Cancer

原文发布日期：24 January 2024

DOI: 10.3390/cancers16030510

类型: Article

开放获取: 是

英文摘要：

Pigment epithelium-derived factor (PEDF) is a natural immunomodulator, anti-inflammatory, anti-angiogenic, anti-tumour growth and anti-metastasis factor, which can enhance tumour response to PEDF but can also conversely have pro-cancerous effects. Inflammation is a major cause of cancer, and it has been proven that PEDF has anti-inflammatory properties. PEDF’s functional activity can be investigated through measuring metastatic and metabolic biomarkers that will be discussed in this review.

摘要翻译： 

色素上皮衍生因子（PEDF）是一种天然的免疫调节剂，具有抗炎、抗血管生成、抑制肿瘤生长及转移的作用，其既能增强肿瘤对PEDF的反应，也可能产生促癌效应。炎症是诱发癌症的重要因素，已有研究证实PEDF具备抗炎特性。本综述将通过探讨转移性和代谢性生物标志物的检测方法，深入分析PEDF的功能活性。

原文链接：

The Various Roles of PEDF in Cancer