The association between red meat consumption and colorectal cancer has been rigorously examined. However, a more comprehensive understanding of how the intake of unprocessed red meat contributes to the development of early precancerous colorectal lesions, such as advanced colorectal adenomas (ACRAs), requires further investigation. We examined the associations between different types of red meat intake and ACRAs in a sample population of 1083 individuals aged ≥ 50 years undergoing an initial screening colonoscopy in Calgary, Alberta, Canada. Associations between grams per day of total, processed, and unprocessed red meat from diet history questionnaires and ACRAs were evaluated with multivariable logistic regression models. We also applied cubic spline models fitted with three knots (10th, 50th, and 90th percentiles) to identify potential nonlinear associations. We did not observe a meaningful association between unprocessed red meat intake and the presence of ACRAs. In contrast, for every 10 g/d increase in total and processed meat intake, we observed an increase in the odds of ACRAs at the screening colonoscopy (adjusted odds ratio (OR) = 1.05, 95% [CI = 1.01–1.09],p= 0.04) and (adjusted OR = 1.11, 95% [CI = 1.02–1.20],p= 0.02), respectively. This study highlights the importance of differentiating between types of red meat consumption in the context of dietary risks associated with ACRAs.
红肉摄入与结直肠癌之间的关联已得到严格验证。然而，关于未加工红肉摄入如何促进早期结直肠癌前病变（如进展期结直肠腺瘤）发展的机制，仍需更深入的研究。我们在加拿大阿尔伯塔省卡尔加里市对1083名年龄≥50岁、首次接受结肠镜筛查的人群样本中，研究了不同类型红肉摄入与进展期结直肠腺瘤的关联。通过多变量逻辑回归模型评估膳食史问卷中总红肉、加工红肉及未加工红肉每日摄入克数与进展期结直肠腺瘤的关联，并采用设置三个节点（第10、50、90百分位数）的立方样条模型识别潜在非线性关联。结果显示未加工红肉摄入与进展期结直肠腺瘤存在无显著统计学意义的关联。与之相对，总红肉与加工红肉摄入量每增加10克/日，结肠镜筛查中进展期结直肠腺瘤的检出风险分别相应提升（调整后比值比=1.05，95%置信区间1.01–1.09，p=0.04）与（调整后比值比=1.11，95%置信区间1.02–1.20，p=0.02）。本研究强调了在评估进展期结直肠腺瘤饮食风险时，区分红肉类型的重要性。
肿瘤(癌症)患者之家