文章：

HOTAIR、MIR155HG、TERC、miR-155、-196a2及-146a基因多态性与甲状腺乳头状癌易感性及预后的关联研究

Association of HOTAIR, MIR155HG, TERC, miR-155, -196a2, and -146a Genes Polymorphisms with Papillary Thyroid Cancer Susceptibility and Prognosis

原文发布日期：23 January 2024

DOI: 10.3390/cancers16030485

类型: Article

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英文摘要：

Polymorphisms in long non-coding RNA and microRNA genes may play a significant role in the susceptibility and progression of papillary thyroid carcinoma (PTC). The current study investigates the polymorphisms HOTAIR rs920778, MIR155HG rs1893650, TERC rs10936599, miR-155 rs767649, miR-196a2 rs11614913 and miR-146a rs2910164 in 102 PTC patients and 106 age- and sex-matched controls of the Caucasian Serbian population, using real-time PCR. We observed differences in genotype distributions of the HOTAIR rs920778 (p= 0.016) and MIR155HG rs1893650 (p= 0.0002) polymorphisms between PTC patients and controls. HOTAIR rs920778 was associated with increased PTC susceptibility (adjusted OR = 1.497,p= 0.021), with the TT variant genotype increasing the risk compared to the CC genotype (OR = 2.466,p= 0.012) and C allele carriers (CC + CT) (OR = 1.585,p= 0.006). The HOTAIR rs920778 TT genotype was associated with lymph node metastasis (p= 0.022), tumor recurrence (p= 0.016), and progression-free survival (p= 0.010) compared to C allele carriers. Multivariate Cox regression revealed that ATA risk (HR = 14.210,p= 0.000004) and HOTAIR rs920778 (HR = 2.811,p= 0.010) emerged as independent prognostic factors in PTC. A novel polymorphism, MIR155HG rs1893650, was negatively correlated with susceptibility to PTC, with TC heterozygotes exerting a protective effect (OR = 0.268,p= 0.0001). These results suggest that the polymorphisms HOTAIR rs920778 and MIR155HG rs1893650 could be potential prognostic and risk biomarkers in papillary thyroid carcinomas.

摘要翻译： 

长链非编码RNA与微小RNA基因多态性可能在甲状腺乳头状癌（PTC）的易感性和进展中发挥重要作用。本研究通过实时荧光定量PCR技术，对102例PTC患者及106例年龄性别匹配的塞尔维亚高加索人群对照，检测了HOTAIR rs920778、MIR155HG rs1893650、TERC rs10936599、miR-155 rs767649、miR-196a2 rs11614913和miR-146a rs2910164多态位点。研究发现PTC患者与对照组在HOTAIR rs920778（p=0.016）和MIR155HG rs1893650（p=0.0002）的基因型分布存在显著差异。HOTAIR rs920778与PTC易感性增加相关（校正OR=1.497，p=0.021），其中TT变异基因型较CC基因型（OR=2.466，p=0.012）及C等位基因携带者（CC+CT）（OR=1.585，p=0.006）显著增加患病风险。与C等位基因携带者相比，HOTAIR rs920778 TT基因型与淋巴结转移（p=0.022）、肿瘤复发（p=0.016）及无进展生存期（p=0.010）显著相关。多变量Cox回归分析显示ATA风险分层（HR=14.210，p=0.000004）和HOTAIR rs920778（HR=2.811，p=0.010）是PTC的独立预后因素。新发现的MIR155HG rs1893650多态位点与PTC易感性呈负相关，TC杂合基因型具有保护作用（OR=0.268，p=0.0001）。这些结果表明，HOTAIR rs920778和MIR155HG rs1893650多态性可能成为甲状腺乳头状癌潜在的预后与风险生物标志物。

原文链接：

Association of HOTAIR, MIR155HG, TERC, miR-155, -196a2, and -146a Genes Polymorphisms with Papillary Thyroid Cancer Susceptibility and Prognosis