文章：

新辅助治疗后局部晚期直肠癌根治性切除术后晚期局部复发

Late Local Recurrence after Neoadjuvant Therapy and Radical Resection for Locally Advanced Rectal Cancer

原文发布日期：20 January 2024

DOI: 10.3390/cancers16020448

类型: Article

开放获取: 是

英文摘要：

Neoadjuvant radiochemotherapy (RCT) and lately total neoadjuvant therapy (TNT) improved local recurrence rates of rectal cancer significantly compared to total mesorectal excision (TME) alone. Yet the occurrence and impact of late local recurrences after many years appears to be a distinct biological problem. We includedn= 188 patients with rectal cancer after RCT and radical resection in this study;n= 38 of which had recurrent disease (sites: local (8.0%), liver (6.4%), lung (3.7%)). We found that 68% of all recurrences developed within the first two years. Four patients, however, experience recurrence >8 years after surgery. Here, we report and characterize four cases of late local recurrence (10% of patients with recurrent disease), suggesting that neoadjuvant therapy in principle delays local recurrence.

摘要翻译： 

与单纯全直肠系膜切除术（TME）相比，新辅助放化疗（RCT）及近年兴起的全周期新辅助治疗（TNT）显著降低了直肠癌的局部复发率。然而，术后多年出现的晚期局部复发及其影响，似乎是一个独特的生物学问题。本研究纳入188例接受RCT及根治性切除术的直肠癌患者，其中38例出现疾病复发（复发部位：局部8.0%、肝脏6.4%、肺部3.7%）。研究发现68%的复发发生在术后前两年内，但另有4例患者在术后8年以上出现复发。本文报告并分析了4例晚期局部复发病例（占复发患者的10%），提示新辅助治疗本质上可能延缓了局部复发的发生时间。

原文链接：

Late Local Recurrence after Neoadjuvant Therapy and Radical Resection for Locally Advanced Rectal Cancer