文章：

HOTAIR基因rs920778与rs12826786遗传变异在膀胱癌发病风险及生存预后中的相关性研究

Relevance ofHOTAIRrs920778 and rs12826786 Genetic Variants in Bladder Cancer Risk and Survival

原文发布日期：19 January 2024

DOI: 10.3390/cancers16020434

类型: Article

开放获取: 是

英文摘要：

The long non-coding RNA HOX transcript antisense intergenic RNA (HOTAIR) is associated with oncogenic features in bladder cancer and is predictive of poor clinical outcomes in patients diagnosed with this disease. In this study, we evaluated the impact of theHOTAIRsingle nucleotide polymorphisms rs920778 and rs12826786 on bladder cancer risk and survival. This case-control study included 106 bladder cancer patients and 199 cancer-free controls. Polymorphisms were evaluated through PCR-restriction fragment length polymorphism. The odds ratio and 95% confidence intervals were tested using univariable and multivariable logistic regressions. The effects on patient survival were evaluated using the log-rank test and Cox regression models. Our data showed that theHOTAIRrs920778 and rs12826786 genetic variants are not associated with the risk of developing bladder cancer. Nevertheless, survival analyses suggested that theHOTAIRrs920778 TT genotype and rs12826786 CC genotype are associated with increased survival in male bladder cancer patients and in patients, both male and female, who have primary tumors with a pathological stage of pT2. Together, these results suggest that, despite not being associated with bladder cancer risk,HOTAIRrs920778 and rs12826786 polymorphisms might represent new prognostic factors in this type of cancer. This is particularly important as these polymorphisms might be easily evaluated in bladder cancer patients in a minimally invasive manner to better predict their clinical outcomes.

摘要翻译： 

长链非编码RNA HOX转录反义基因间RNA（HOTAIR）与膀胱癌的致癌特征相关，并能预测该疾病患者的不良临床结局。本研究评估了HOTAIR单核苷酸多态性rs920778和rs12826786对膀胱癌风险及生存期的影响。该病例对照研究纳入了106例膀胱癌患者和199例无癌对照者。通过PCR-限制性片段长度多态性技术评估多态性，采用单变量及多变量逻辑回归检验比值比及95%置信区间，并运用对数秩检验和Cox回归模型评估对患者生存期的影响。数据显示HOTAIR rs920778和rs12826786基因变异与膀胱癌发病风险无显著关联。然而，生存分析表明，HOTAIR rs920778 TT基因型和rs12826786 CC基因型与男性膀胱癌患者、以及病理分期为pT2的原发性肿瘤患者（包括男性和女性）的生存期延长相关。综上，这些结果表明尽管HOTAIR rs920778和rs12826786多态性与膀胱癌风险无关，但可能成为该癌症的新型预后因子。这一发现尤为重要，因为这些多态性可通过微创方式在膀胱癌患者中便捷检测，从而更好地预测其临床结局。

原文链接：

Relevance ofHOTAIRrs920778 and rs12826786 Genetic Variants in Bladder Cancer Risk and Survival