文章：

ELF5：乳腺衰老与癌症易感性的分子时钟

ELF5: A Molecular Clock for Breast Aging and Cancer Susceptibility

原文发布日期：19 January 2024

DOI: 10.3390/cancers16020431

类型: Article

开放获取: 是

英文摘要：

Breast cancer is predominantly an age-related disease, with aging serving as the most significant risk factor, compounded by germline mutations in high-risk genes likeBRCA1/2. Aging induces architectural changes in breast tissue, particularly affecting luminal epithelial cells by diminishing lineage-specific molecular profiles and adopting myoepithelial-like characteristics. ELF5 is an important transcription factor for both normal breast and breast cancer development. This review focuses on the role of ELF5 in normal breast development, its altered expression throughout aging, and its implications in cancer. It discusses the lineage-specific expression of ELF5, its regulatory mechanisms, and its potential as a biomarker for breast-specific biological age and cancer risk.

摘要翻译： 

乳腺癌主要是一种与年龄相关的疾病，衰老是其最重要的风险因素，而BRCA1/2等高危基因的种系突变进一步加剧了这一风险。衰老会导致乳腺组织结构发生变化，尤其影响管腔上皮细胞，使其谱系特异性分子特征减弱并呈现肌上皮样特性。ELF5是正常乳腺发育及乳腺癌发生过程中的重要转录因子。本综述聚焦于ELF5在正常乳腺发育中的作用、其在衰老过程中的表达变化及其在癌症中的意义，探讨了ELF5的谱系特异性表达、调控机制，以及其作为乳腺特异性生物学年龄和癌症风险生物标志物的潜力。

原文链接：

ELF5: A Molecular Clock for Breast Aging and Cancer Susceptibility