Weight loss is a significant health problem among patients with head and neck cancer (HNC) that is attributable primarily to the tumor or tumor therapy. Critical weight loss (CWL) is defined as the unintentional loss of ≥5% of weight. Therefore, this study’s goal was to investigate and determine the possible factors influencing CWL among patients with HNC who have received radiotherapy or concurrent chemoradiotherapy (CCRT). We conducted a retrospective analysis of 175 patients who received radiotherapy or CCRT as either their primary, adjuvant, or combined treatment at the Oncology Center in King Abdullah Medical City. All patients were ≥18 years of age and diagnosed with HNC with no metastasis. The study results showed that 107 patients (61%) had CWL, while 68 (39%) did not. The following factors were significantly predictive of CWL with a multivariate regression analysis: pretreatment BMI (AOR = 1.1, 95% CI = 1.02–1.17), oral cavity cancer (AOR = 10.36, 95% CI = 1.13–94.55), and male sex (AOR = 3.15, 95% CI = 1.39–7.11). In conclusion, weight loss is highly prevalent among HNC patients during treatment. Accordingly, pretreatment BMI, cancer in the oral cavity, and being male can be considered predictive factors for CWL.
体重减轻是头颈癌患者面临的重要健康问题，主要归因于肿瘤本身或肿瘤治疗。临界体重减轻定义为非自主性体重下降≥5%。本研究旨在探讨并确定影响接受放疗或同步放化疗的头颈癌患者发生临界体重减轻的可能因素。我们对阿卜杜拉国王医疗城肿瘤中心收治的175例患者进行了回顾性分析，这些患者均接受放疗或同步放化疗作为主要治疗、辅助治疗或联合治疗方案。所有患者年龄≥18岁，确诊为无转移头颈癌。研究结果显示，107例患者发生临界体重减轻，发生率为61%；68例未发生，占39%。多因素回归分析显示以下因素对临界体重减轻具有显著预测价值：治疗前体重指数、口腔癌以及男性性别。综上，体重减轻在头颈癌治疗期间极为普遍。治疗前体重指数、口腔癌及男性性别可作为临界体重减轻的预测因素。
肿瘤(癌症)患者之家