文章：

人乳头瘤病毒感染与宫颈及宫颈阴道微生物群的作用——基于下一代测序研究的证据

Human Papillomavirus Infections and the Role Played by Cervical and Cervico-Vaginal Microbiota—Evidence from Next-Generation Sequencing Studies

原文发布日期：17 January 2024

DOI: 10.3390/cancers16020399

类型: Article

开放获取: 是

英文摘要：

This comprehensive review encompasses studies examining changes in the cervical and cervico-vaginal microbiota (CM and CVM) in relation to human papillomavirus (HPV) using next-generation sequencing (NGS) technology. HPV infection remains a prominent global health concern, with a spectrum of manifestations, from benign lesions to life-threatening cervical cancers. The CM and CVM, a unique collection of microorganisms inhabiting the cervix/vagina, has emerged as a critical player in cervical health. Recent research has indicated that disruptions in the CM and CVM, characterized by a decrease inLactobacillusand the overgrowth of other bacteria, might increase the risk of HPV persistence and the progression of cervical abnormalities. This alteration in the CM or CVM has been linked to a higher likelihood of HPV infection and cervical dysplasia. NGS technology has revolutionized the study of the cervical microbiome, providing insights into microbial diversity, dynamics, and taxonomic classifications. Bacterial16S rRNAgene sequencing, has proven invaluable in characterizing the cervical microbiome, shedding light on its role in HPV infections and paving the way for more tailored strategies to combat cervical diseases. NGS-based studies offer personalized insights into an individual’s cervical microbiome. This knowledge holds promise for the development of novel diagnostic tools, targeted therapies, and preventive interventions for cervix-related conditions, including cervical cancer.

摘要翻译： 

本综述系统梳理了运用新一代测序技术探究宫颈及宫颈阴道微生物群与人类乳头瘤病毒关联的研究进展。HPV感染作为全球重大公共卫生问题，其临床表现可从良性病变延伸至危及生命的宫颈癌。定植于宫颈/阴道的微生物集合体——宫颈及宫颈阴道微生物群，已被证实对宫颈健康具有关键调控作用。最新研究表明，以乳杆菌减少与其他菌群过度增殖为特征的微生物群紊乱，可能增加HPV持续感染及宫颈病变进展风险。这种微生物群失调状态与HPV感染易感性及宫颈不典型增生发生率升高密切相关。新一代测序技术通过解析微生物多样性、动态变化及分类学特征，革新了宫颈微生物组研究范式。基于细菌16S rRNA基因测序的技术体系，在表征宫颈微生物组特征、阐明其在HPV感染中的作用机制方面展现出重要价值，为制定精准宫颈疾病防治策略开辟了新途径。新一代测序研究能够提供个体化宫颈微生物组信息，这些发现有望推动包括宫颈癌在内的宫颈相关疾病的新型诊断工具、靶向治疗方案及预防干预措施的创新发展。

原文链接：

Human Papillomavirus Infections and the Role Played by Cervical and Cervico-Vaginal Microbiota—Evidence from Next-Generation Sequencing Studies