GBM accounts for most of the fatal brain cancer cases, making it one of the deadliest tumor types. GBM is characterized by severe progression and poor prognosis with a short survival upon conventional chemo- and radiotherapy. In order to improve therapeutic efficiency, considerable efforts have been made to target various features of GBM. One of the targetable features of GBM is the rewired lipid metabolism that contributes to the tumor’s aggressive growth and penetration into the surrounding brain tissue. Lipid reprogramming allows GBM to acquire survival, proliferation, and invasion benefits as well as supportive modulation of the tumor microenvironment. Several attempts have been made to find novel therapeutic approaches by exploiting the lipid metabolic reprogramming in GBM. In recent studies, various components ofde novolipogenesis, fatty acid oxidation, lipid uptake, and prostaglandin synthesis have been considered promising targets in GBM. Emerging data also suggest a significant role hence therapeutic potential of the endocannabinoid metabolic pathway in GBM. Here we review the lipid-related GBM characteristics in detail and highlight specific targets with their potential therapeutic use in novel antitumor approaches.
胶质母细胞瘤（GBM）占致命性脑癌病例的大多数，是最致命的肿瘤类型之一。其特点是进展迅速、预后不良，常规化疗和放疗后生存期较短。为提高治疗效果，针对GBM多种特征的研究已取得显著进展。其中可靶向的特征之一是脂质代谢重编程，这种代谢改变促进了肿瘤的侵袭性生长及对周围脑组织的浸润。脂质重编程使GBM获得生存、增殖和侵袭优势，并能调控肿瘤微环境。通过利用GBM的脂质代谢重编程特征，多项研究已尝试开发新型治疗方法。近期研究表明，新生脂质合成、脂肪酸氧化、脂质摄取及前列腺素合成等多个环节的组分均有望成为GBM的治疗靶点。新兴数据还提示内源性大麻素代谢通路在GBM中具有重要作用及治疗潜力。本文详细综述了GBM的脂质相关特征，并重点探讨了可作为新型抗肿瘤策略潜在靶点的特异性目标。
肿瘤(癌症)患者之家