This article presents a comprehensive review of nanoparticle-assisted treatment approaches for soft tissue sarcoma (STS). STS, a heterogeneous group of mesenchymal-origin tumors with aggressive behavior and low overall survival rates, necessitates the exploration of innovative therapeutic interventions. In contrast to conventional treatments like surgery, radiotherapy (RT), hyperthermia (HT), and chemotherapy, nanomedicine offers promising advancements in STS management. This review focuses on recent research in nanoparticle applications, including their role in enhancing RT and HT efficacy through improved drug delivery systems, novel radiosensitizers, and imaging agents. Reviewing the current state of nanoparticle-assisted therapies, this paper sheds light on their potential to revolutionize soft tissue sarcoma treatment and improve patient therapy outcomes.
本文对纳米颗粒辅助治疗软组织肉瘤(STS)的方法进行了全面综述。软组织肉瘤是一组具有侵袭性行为和较低总体生存率的间叶组织来源异质性肿瘤,亟需探索创新的治疗干预手段。相较于手术、放射治疗(RT)、热疗(HT)和化疗等传统疗法,纳米医学为软组织肉瘤的治疗管理带来了前景广阔的新进展。本综述聚焦于纳米颗粒应用的最新研究,包括其通过改进药物递送系统、新型放射增敏剂和成像剂在增强放射治疗与热疗疗效方面的作用。通过梳理纳米颗粒辅助疗法的现状,本文揭示了其在革新软组织肉瘤治疗模式、改善患者疗效方面的巨大潜力。