文章：

利用功能衰退与恶病质的系统生物学，为不治之症癌症提供更全面的治疗策略

Harnessing the Systemic Biology of Functional Decline and Cachexia to Inform more Holistic Therapies for Incurable Cancers

原文发布日期：14 January 2024

DOI: 10.3390/cancers16020360

类型: Article

开放获取: 是

英文摘要：

Options for treatment of incurable cancer remain scarce and are largely focused on limited therapeutic mechanisms. A new approach specific to advanced cancers is needed to identify new and effective treatments. Morbidity in advanced cancer is driven by functional decline and a number of systemic conditions, including cachexia and fatigue. This review will focus on these clinical concepts, describe our current understanding of their underlying biology, and then propose how future therapeutic strategies, including pharmaceuticals, exercise, and rehabilitation, could target these mechanisms as an alternative route to addressing incurable cancer.

摘要翻译： 

对于无法治愈的癌症，目前治疗选择依然有限，且大多集中于少数几种治疗机制。针对晚期癌症，亟需一种新方法来发现新的有效治疗手段。晚期癌症的发病主要由功能衰退及一系列全身性症状（如恶病质和疲劳）驱动。本综述将聚焦这些临床概念，阐述当前对其生物学基础的理解，并探讨未来治疗策略（包括药物治疗、运动及康复治疗）如何针对这些机制，为应对无法治愈的癌症提供替代途径。

原文链接：

Harnessing the Systemic Biology of Functional Decline and Cachexia to Inform more Holistic Therapies for Incurable Cancers