(1) Background: Pancreatic adenocarcinoma (PAC) is one of the most lethal types of cancer. Most cases of PAC occur in the head of the pancreas. Given the proximity of the pancreatic head to the bile duct, most patients present clinically during early stages of the disease, while distally located PAC could have delayed clinical presentation. (2) Aims: To assess predictors of non-head PAC. (3) Methods: A retrospective multicenter study was conducted, including all patients who had endoscopic ultrasound (EUS) for pancreatic masses and who had histologic confirmation of PAC. (4) Results: Of the 151 patients included, 92 (60.9%) had pancreatic head cancer, and 59 (39.1%) had distal pancreatic cancer. PAC at body was the most common location in the distal PAC group (31 patients (52.5%)). Logistic regression analysis demonstrated a significant association of obesity with distal migration of PAC (OR 4.44, 95% CI 1.15–17.19,p= 0.03), while none of the other assessed parameters showed a significant association. Notably, abdominal pain was more significantly associated with distal PAC vs. head location (OR 2.85, 95% CI 1.32–6.16,p= 0.008). (5) Conclusions: Obesity shows a significant association as a clinical predictor of distal PAC. Further studies are needed to better explore this association.
(1) 背景：胰腺导管腺癌（PAC）是致死率最高的恶性肿瘤之一。多数PAC发生于胰头部。鉴于胰头与胆管的解剖毗邻关系，大多数患者在疾病早期即出现临床症状，而位于胰腺远端的PAC可能出现临床表现延迟。(2) 目的：评估非胰头部PAC的预测因素。(3) 方法：开展一项多中心回顾性研究，纳入所有因胰腺占位性病变接受超声内镜（EUS）检查并经组织学确诊为PAC的患者。(4) 结果：在纳入的151例患者中，92例（60.9%）为胰头癌，59例（39.1%）为胰腺远端癌。在远端PAC组中，胰体部是最常见发病部位（31例，占52.5%）。逻辑回归分析显示肥胖与PAC远端移位存在显著相关性（OR 4.44，95% CI 1.15–17.19，p=0.03），而其他评估参数均未显示显著关联。值得注意的是，与胰头部位相比，腹痛与远端PAC的关联性更为显著（OR 2.85，95% CI 1.32–6.16，p=0.008）。(5) 结论：肥胖作为远端PAC的临床预测指标具有显著相关性，需进一步研究以深入探讨该关联机制。
肿瘤(癌症)患者之家