In recent decades, the improvement of treatments and the adoption of therapeutic protocols of international cooperation has led to an improvement in the survival of children affected by brain tumors. However, in parallel with the increase in survival, long-term side effects related to treatments have been observed over time, including the activation of chronic inflammatory processes and metabolic alterations, which can facilitate the onset of metabolic syndrome and increased cardiovascular risk. The aim of this study was to find possible statistically significant differences in the serum concentrations of early biomarkers of metabolic syndrome and in the results of cardiopulmonary exercise testing between survivors of childhood brain tumors and healthy controls. This is a prospective and observational study conducted on a group of 14 male patients who survived childhood brain tumors compared with the same number of healthy controls. The concentrations of early metabolic syndrome biomarkers [adiponectin, leptin, TNF-α, IL-1, IL-6, IL-10, endothelin-1, apolipoprotein B, and lipoprotein (a)] were measured and a cardiopulmonary exercise test (CPET) was performed. Results: Childhood brain tumor survivors performed worse on average than controls on the CPET. Furthermore, they showed higher endothelin-1 values than controls (p= 0.025). The CPET results showed an inverse correlation with leptin. The differences found highlight the greater cardiovascular risk of brain tumor survivors, and radiotherapy could be implicated in the genesis of this greater cardiovascular risk.
近几十年来，治疗方案的改进与国际合作治疗方案的采用，使得罹患脑肿瘤儿童的生存率有所提高。然而，随着生存率的提升，治疗相关的长期副作用也逐渐显现，包括慢性炎症过程的激活和代谢改变，这些都可能促进代谢综合征的发生并增加心血管风险。本研究旨在探讨儿童脑肿瘤幸存者与健康对照组之间，在代谢综合征早期生物标志物的血清浓度以及心肺运动试验结果上是否存在统计学显著差异。这是一项前瞻性观察研究，对14名男性儿童脑肿瘤幸存者与同等数量的健康对照组进行了比较。测量了早期代谢综合征生物标志物[脂联素、瘦素、TNF-α、IL-1、IL-6、IL-10、内皮素-1、载脂蛋白B和脂蛋白(a)]的浓度，并进行了心肺运动试验。结果：儿童脑肿瘤幸存者在心肺运动试验中的平均表现差于对照组。此外，他们的内皮素-1值高于对照组（p=0.025）。心肺运动试验结果与瘦素呈负相关。这些差异凸显了脑肿瘤幸存者更高的心血管风险，而放疗可能是导致这种更高心血管风险的原因之一。
肿瘤(癌症)患者之家