文章：

结直肠癌腹膜转移的细胞减灭术与腹腔热灌注化疗——现状与未来展望综述

Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Metastases from Colorectal Cancer—An Overview of Current Status and Future Perspectives

原文发布日期：9 January 2024

DOI: 10.3390/cancers16020284

类型: Article

开放获取: 是

英文摘要：

Peritoneal metastases (PM) are observed in approximately 8% of patients diagnosed with colorectal cancer, either synchronously or metachronously during follow-up. PM often manifests as the sole site of metastasis. PM is associated with a poor prognosis and typically shows resistance to systemic chemotherapy. Consequently, there has been a search for alternative treatment strategies. This review focuses on the global evolution of the combined approach involving cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for the management of PM. It encompasses accepted clinical guidelines, principles for patient selection, surgical and physiological considerations, biomarkers, pharmacological protocols, and treatment outcomes. Additionally, it integrates the relevant literature and findings from previous studies. The role of CRS and HIPEC, in conjunction with other therapies such as neoadjuvant and adjuvant chemotherapy, is discussed, along with the management of patients presenting with oligometastatic disease. Furthermore, potential avenues for future development in this field are explored.

摘要翻译： 

结直肠癌患者中约8%在确诊时或随访期间出现腹膜转移，且常作为唯一转移部位。腹膜转移预后较差，通常对全身化疗不敏感，因此需要探索替代治疗策略。本综述聚焦于细胞减灭术联合腹腔热灌注化疗这一综合治疗策略在全球范围内的发展历程，涵盖临床指南共识、患者选择原则、手术与生理学考量、生物标志物、药物方案及治疗结局，并整合相关文献与既往研究结果。文中探讨了细胞减灭术联合腹腔热灌注化疗与新辅助/辅助化疗等其他疗法的协同作用，以及寡转移患者的临床管理策略，同时展望了该领域未来的发展方向。

原文链接：

Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Metastases from Colorectal Cancer—An Overview of Current Status and Future Perspectives