Colony-stimulating factor 1 receptor (CFS-1R) is a myeloid receptor with a crucial role in monocyte survival and differentiation. Its overexpression is associated with aggressive tumors characterized by an immunosuppressive microenvironment and poor prognosis. CSF-1R ligands, IL-34 and M-CSF, are produced by many cells in the tumor microenvironment (TME), suggesting a key role for the receptor in the crosstalk between tumor, immune and stromal cells in the TME. Recently, CSF-1R expression was reported in the cell membrane of the cancer cells of different solid tumors, capturing the interest of various research groups interested in investigating the role of this receptor in non-myeloid cells. This review summarizes the current data available on the expression and activity of CSF-1R in different tumor types. Notably, CSF-1R+cancer cells have been shown to produce CSF-1R ligands, indicating that CSF-1R signaling is positively regulated in an autocrine manner in cancer cells. Recent research demonstrated that CSF-1R signaling enhances cell transformation by supporting tumor cell proliferation, invasion, stemness and drug resistance. In addition, this review covers recent therapeutic strategies, including monoclonal antibodies and small-molecule inhibitors, targeting the CSF-1R and designed to block the pro-oncogenic role of CSF-1R in cancer cells.
集落刺激因子1受体（CSF-1R）是一种在单核细胞存活与分化过程中起关键作用的髓系受体。其过度表达与侵袭性肿瘤相关，这类肿瘤通常具有免疫抑制性微环境且预后不良。CSF-1R的配体IL-34和M-CSF由肿瘤微环境（TME）中多种细胞产生，提示该受体在TME内肿瘤细胞、免疫细胞及基质细胞的相互作用中发挥核心作用。近期研究发现，多种实体瘤的癌细胞膜表面存在CSF-1R表达，这引起了多个研究团队对非髓系细胞中该受体功能的关注。本综述系统总结了当前关于不同肿瘤类型中CSF-1R表达与活性的研究数据。值得注意的是，CSF-1R阳性癌细胞可产生CSF-1R配体，表明癌细胞中CSF-1R信号通过自分泌方式被正向调控。最新研究证实，CSF-1R信号通过促进肿瘤细胞增殖、侵袭、维持干细胞特性及耐药性来增强细胞转化。此外，本文还综述了针对CSF-1R的最新治疗策略，包括旨在阻断该受体在癌细胞中促癌作用的单克隆抗体与小分子抑制剂。
肿瘤(癌症)患者之家