Minimal-invasive resection of the esophagus for esophageal cancer has led to a relevant decrease in postoperative morbidity. Postoperatively, patients still suffer from surgical and adjuvant therapy-related symptoms impairing nutrition and quality of life. The aim of this study was to evaluate the nutritional status and associated symptoms six months after esophagectomy. Patients who attended follow-up examination six months after minimal-invasive esophagectomy were included. Blood and fecal tests, quality of life surveys (QLQ-C30 and QLQ-OG25) and nutritional risk screening (NRS) were performed. Twenty-four patients participated. The mean weight loss was 11 kg. A significant decrease in vitamin B12 (737 to 467 pg/mL;p= 0.033), ferritin (302 to 126 ng/mL;p= 0.012) and haptoglobin (227 to 152 mg/dL;p= 0.025) was found. In total, 47% of the patients had an impaired pancreatic function (fecal elastase < 500 µg/g). Physical (72 to 58;p= 0.034) and social functioning (67 to 40;p= 0.022) was significantly diminished, while self-reported global health status remained stable (52 to 54). The number of patients screened and found to be in need of nutritional support according to NRS score decreased slightly (59% to 52%). After MIE, patients should be meticulously monitored for nutritional status after surgery.
食管癌微创切除术显著降低了术后并发症发生率。然而术后患者仍受手术及辅助治疗相关症状困扰，这些症状影响营养状况与生活质量。本研究旨在评估食管切除术后六个月患者的营养状况及相关症状。研究纳入微创食管切除术后六个月接受随访检查的患者，进行血液与粪便检测、生活质量问卷调查（QLQ-C30与QLQ-OG25量表）及营养风险筛查（NRS）。共24例患者参与研究，平均体重下降11公斤。维生素B12（从737降至467 pg/mL；p=0.033）、铁蛋白（从302降至126 ng/mL；p=0.012）及触珠蛋白（从227降至152 mg/dL；p=0.025）水平显著下降。总体而言，47%的患者存在胰腺功能受损（粪便弹性蛋白酶<500 µg/g）。躯体功能（从72降至58；p=0.034）与社会功能（从67降至40；p=0.022）显著下降，而自我报告的整体健康状况保持稳定（从52至54）。根据NRS评分筛查需要营养支持的患者比例略有下降（从59%降至52%）。微创食管切除术后，应对患者术后营养状况进行严密监测。
肿瘤(癌症)患者之家