文章：

循环肿瘤细胞在预测骨转移中的作用

Circulating Tumour Cells in the Prediction of Bone Metastasis

原文发布日期：5 January 2024

DOI: 10.3390/cancers16020252

类型: Article

开放获取: 是

英文摘要：

Bone is the most common organ for the development of metastases in many primary tumours, including those of the breast, prostate and lung. In most cases, bone metastasis is incurable, and treatment is predominantly palliative. Much research has focused on the role of Circulating Tumour Cells (CTCs) in the mechanism of metastasis to the bone, and methods have been developed to isolate and count CTCs from peripheral blood. Several methods are currently being used in the study of CTCs, but only one, the CellSearchTM system has been approved by the United States Food and Drug Administration for clinical use. This review summarises the advantages and disadvantages, and outlines which clinical studies have used these methods. Studies have found that CTC numbers are predictive of bone metastasis in breast, prostate and lung cancer. Further work is required to incorporate information on CTCs into current staging systems to guide treatment in the prevention of tumour progression into bone.

摘要翻译： 

骨骼是多种原发性肿瘤（包括乳腺癌、前列腺癌和肺癌）最常见的转移靶器官。在多数情况下，骨转移难以治愈，治疗主要以姑息性疗法为主。大量研究聚焦于循环肿瘤细胞在骨转移机制中的作用，并已开发出从外周血中分离和计数循环肿瘤细胞的方法。目前已有多种方法应用于循环肿瘤细胞研究，但其中仅有CellSearchTM系统获得美国食品药品监督管理局批准用于临床。本综述总结了这些方法的优缺点，并概述了相关临床研究中的应用情况。研究发现，循环肿瘤细胞数量对乳腺癌、前列腺癌和肺癌的骨转移具有预测价值。未来需进一步探索如何将循环肿瘤细胞信息整合至现有分期系统，以指导临床制定预防肿瘤骨转移进展的治疗策略。

原文链接：

Circulating Tumour Cells in the Prediction of Bone Metastasis