文章：

黑色素瘤抗原家族A（MAGE A）作为膀胱癌中具有前景的生物标志物与治疗靶点

Melanoma Antigen Family A (MAGE A) as Promising Biomarkers and Therapeutic Targets in Bladder Cancer

原文发布日期：5 January 2024

DOI: 10.3390/cancers16020246

类型: Article

开放获取: 是

英文摘要：

The Melanoma Antigen Gene (MAGE) is a large family of highly conserved proteins that share a common MAGE homology domain. Interestingly, many MAGE family members exhibit restricted expression in reproductive tissues but are abnormally expressed in various human malignancies, including bladder cancer, which is a common urinary malignancy associated with high morbidity and mortality rates. The recent literature suggests a more prominent role for MAGEA family members in driving bladder tumorigenesis. This review highlights the role of MAGEA proteins, the potential for them to serve as diagnostic or prognostic biomarker(s), and as therapeutic targets for bladder cancer.

摘要翻译： 

黑色素瘤抗原基因（MAGE）是一个包含高度保守蛋白质的大型家族，其成员均具有共同的MAGE同源结构域。值得注意的是，许多MAGE家族成员在生殖组织中呈限制性表达，却在包括膀胱癌在内的多种人类恶性肿瘤中异常表达。膀胱癌作为常见的泌尿系统恶性肿瘤，具有高发病率与高死亡率的特点。近期研究表明，MAGEA家族成员在驱动膀胱肿瘤发生发展中具有重要作用。本综述重点探讨MAGEA蛋白在膀胱癌中的生物学功能、作为诊断或预后生物标志物的潜力，以及其作为膀胱癌治疗靶点的应用前景。

原文链接：

Melanoma Antigen Family A (MAGE A) as Promising Biomarkers and Therapeutic Targets in Bladder Cancer