Recent advances in oncological research have highlighted the potential of naturally derived compounds in cancer prevention and treatment. Notably, sulforaphane (SFN), an isothiocyanate derived from cruciferous vegetables including broccoli and cabbage, has exhibited potent chemosensitizing capabilities across diverse cancer types of bone, brain, breast, lung, skin, etc. Chemosensitization refers to the enhancement of cancer cell sensitivity to chemotherapy agents, counteracting the chemoresistance often developed by tumor cells. Mechanistically, SFN orchestrates this sensitization by modulating an array of cellular signaling pathways (e.g., Akt/mTOR, NF-κB, Wnt/β-catenin), and regulating the expression and activity of pivotal genes, proteins, and enzymes (e.g., p53, p21, survivin, Bcl-2, caspases). When combined with conventional chemotherapeutic agents, SFN synergistically inhibits cancer cell proliferation, invasion, migration, and metastasis while potentiating drug-induced apoptosis. This positions SFN as a potential adjunct in cancer therapy to augment the efficacy of standard treatments. Ongoing preclinical and clinical investigations aim to further delineate the therapeutic potential of SFN in oncology. This review illuminates the multifaceted role of this phytochemical, emphasizing its potential to enhance the therapeutic efficacy of anti-cancer agents, suggesting its prospective contributions to cancer chemosensitization and management.
肿瘤学研究的最新进展凸显了天然来源化合物在癌症预防和治疗中的潜力。值得注意的是，萝卜硫素（SFN）——一种从西兰花、卷心菜等十字花科蔬菜中提取的异硫氰酸盐——已在骨、脑、乳腺、肺、皮肤等多种癌症类型中展现出强大的化疗增敏能力。化疗增敏是指增强癌细胞对化疗药物的敏感性，以对抗肿瘤细胞常产生的化疗耐药性。从机制上看，SFN通过调控一系列细胞信号通路（如Akt/mTOR、NF-κB、Wnt/β-catenin），并调节关键基因、蛋白和酶（如p53、p21、survivin、Bcl-2、caspases）的表达与活性，从而协调实现这种增敏作用。当与传统化疗药物联合使用时，SFN能协同抑制癌细胞的增殖、侵袭、迁移和转移，同时增强药物诱导的细胞凋亡。这使得SFN有望成为癌症治疗中增强标准疗法疗效的潜在辅助手段。当前正在进行的临床前和临床研究旨在进一步阐明SFN在肿瘤学中的治疗潜力。本综述阐明了这种植物化学物质的多方面作用，强调其提升抗癌药物疗效的潜力，并揭示其在癌症化疗增敏与管理中的前瞻性贡献。
Harnessing Sulforaphane Potential as a Chemosensitizing Agent: A Comprehensive Review
肿瘤(癌症)患者之家