The incidence of human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is rising in the West, but little is known in Asia. This study elucidated changes in the incidence and HPV-positive portion of OPSCC in Hong Kong. Data from population-based cancer registry were used to analyze the incidence of OPSCC in association with other head and neck cancers. Archived tumor tissues were tested for HPV. From 1986 to 2020, there was a marked decrease in the incidence of nasopharyngeal and laryngeal cancers, but a persistent increase in OPSCC from 36 cases in 1986 to 116 cases in 2020. The average positive rate for high-risk HPV was 36.1% (112/310) among OPSCC diagnosed in 2010–2020. The HPV-positive rate in recent years was significantly higher than earlier cases (tonsil SCC: 64.7% (55/85) in 2016–2020 vs. 40.4% (19/47) in 2010–2015,p= 0.007). Patients with HPV-positive tonsil cancers were significantly younger than those negative (mean [SD]: 58.9 [9.9] vs. 64.3 [13.3] years,p= 0.006), but no significant difference was observed between genders. A persistent increase in the incidence of oropharyngeal cancer over the last few decades was observed in Hong Kong, which can be explained by the remarkable increase in HPV-positive tonsil cancers.
人乳头瘤病毒（HPV）相关口咽鳞状细胞癌（OPSCC）在西方国家的发病率呈上升趋势，但在亚洲地区相关研究较少。本研究旨在阐明香港地区OPSCC发病率及其HPV阳性比例的变化趋势。通过基于人群的癌症登记数据，分析了OPSCC与其他头颈部癌症的发病率关联，并对存档肿瘤组织进行了HPV检测。1986年至2020年间，鼻咽癌和喉癌发病率显著下降，而OPSCC病例数从1986年的36例持续增长至2020年的116例。2010-2020年间诊断的OPSCC病例中，高危型HPV平均阳性率为36.1%（112/310）。近年HPV阳性率显著高于早期病例（扁桃体鳞癌：2016-2020年为64.7%（55/85） vs 2010-2015年40.4%（19/47），p=0.007）。HPV阳性扁桃体癌患者平均年龄显著低于阴性患者（均值[标准差]：58.9[9.9]岁 vs 64.3[13.3]岁，p=0.006），但性别间无显著差异。香港地区口咽癌发病率在过去数十年持续上升，主要归因于HPV阳性扁桃体癌的显著增加。
肿瘤(癌症)患者之家