Background: Polymorphous adenocarcinoma (PAC) is the second-most common malignant tumour of the minor salivary glands. Although PAC predominantly affects the palate, it can also involve the buccal mucosa. This systematic review aims to investigate the literature data about PAC. Furthermore, we report two cases of patients affected by PAC in an infrequently considered anatomical site. Methods: According to PRISMA guidelines, a systematic review search was conducted on PubMed, Scopus, and Web of Science. Observational studies conducted on patients with a histological diagnosis of PAC were selected and analysed. Furthermore, two cases of patients with PAC affecting the buccal mucosa were reported. Results: Twenty-nine studies were included, and 143 patients affected by PAC were analysed (62 males, 75 females, and 6 undefined, with a mean age of 57.4 ± 14.5 years). The palate was the most affected site (99/143, 69.2%), followed by the buccal mucosa (12/143, 8.4%). Moreover, we report two cases of patients with PAC affecting the buccal mucosa (one male and one female, with a mean age of 70.5 ± 2.5 years). Conclusions: The present study underscores the importance of considering the buccal mucosa as a possible location of minor salivary gland tumours; although it is a less-considered affliction, it is not uncommon.
背景：多形性腺癌（PAC）是第二大常见的小唾液腺恶性肿瘤。尽管PAC主要累及腭部，但也可侵犯颊黏膜。本系统综述旨在探讨有关PAC的文献数据，并报告两例发生于不常见解剖部位的PAC病例。 方法：依据PRISMA指南，在PubMed、Scopus和Web of Science数据库进行系统性文献检索。筛选并分析经组织学诊断为PAC患者的观察性研究，同时报道两例累及颊黏膜的PAC病例。 结果：共纳入29项研究，分析143例PAC患者（男性62例，女性75例，性别未明确6例，平均年龄57.4±14.5岁）。腭部为最常见发病部位（99/143，69.2%），其次为颊黏膜（12/143，8.4%）。此外，本研究报道两例累及颊黏膜的PAC病例（男女各一例，平均年龄70.5±2.5岁）。 结论：本研究强调需重视颊黏膜作为小唾液腺肿瘤潜在发病部位的可能性；尽管该部位较少被关注，但其发病并不罕见。
肿瘤(癌症)患者之家