Surgical treatment is a cornerstone of ovarian cancer (OC) therapy and exerts a substantial influence on the immune system. Immune responses also play a pivotal and intricate role in OC progression. The aim of this study was to investigate the dynamics of immune-related protein expression and the activity of peripheral blood mononuclear cells (PBMCs) in OC patients, both before surgery and during the early postoperative phase. The study cohort comprised 23 OC patients and 20 non-cancer controls. A comprehensive analysis of PBMCs revealed significant pre-operative downregulation in the mRNA expression of multiple immune-related proteins, including interleukins, PD-1, PD-L1, and HO-1. This was followed by further dysregulation during the first 5 post-operative days. Although most serum interleukin concentrations showed only minor changes, a distinct increase in IL-6 and HO-1 levels was observed post-operatively. Reduced metabolic and phagocytic activity and increased production of reactive oxygen species (ROS) were observed on day 1 post-surgery. These findings suggest a shift towards immune tolerance during the early post-operative phase of OC, potentially creating a window for treatment. Further research into post-operative PBMC activity could lead to the development of new or improved treatment strategies for OC.
手术治疗是卵巢癌（OC）治疗的核心手段，并对免疫系统产生显著影响。免疫反应在OC进展中同样发挥着关键且复杂的作用。本研究旨在探讨OC患者术前及术后早期阶段免疫相关蛋白表达的动态变化以及外周血单个核细胞（PBMCs）的活性。研究队列包括23名OC患者和20名非癌症对照者。对PBMCs的综合分析显示，术前多种免疫相关蛋白（包括白细胞介素、PD-1、PD-L1和HO-1）的mRNA表达显著下调，并在术后前5天内进一步失调。尽管大多数血清白细胞介素浓度仅显示微小变化，但术后观察到IL-6和HO-1水平明显升高。术后第1天观察到代谢和吞噬活性降低，活性氧（ROS）产生增加。这些发现表明，在OC术后早期阶段存在向免疫耐受转变的趋势，这可能为治疗创造了一个窗口期。对术后PBMC活性的进一步研究可能有助于开发新的或改进的OC治疗策略。
肿瘤(癌症)患者之家