(1) Background: Infiltration of the aerodigestive tract in advanced thyroid carcinoma determines the prognosis and quality of life. Different stages of tracheal tumor invasion require customization of the surgical concept. (2) Methods: In the period from January 2007 to January 2023, patients who underwent surgery for advanced thyroid carcinomas with trachea resections were included in a retrospective observational study. The surgical resection concepts and operation-associated complications were documented. The overall survival and post-resection survival were analyzed. (3) Results: From 2007 to 2023, at the single-center UMC Mainz, 33 patients (15 female and 18 male) underwent neck surgery with trachea resections for locally advanced thyroid carcinomas. Of these, 14 were treated with non-transmural (trachea shaving) and 19 transmural trachea resections (9 “window” resections, 6 near-circular resections, 3 sleeve resections and 1 total laryngectomy with extramucosal esophageal resection). The two-year postoperative survival rate was 82.0 percent. The two-year recurrence-free survival rate was 75.0 percent (mean follow-up period: 29.2 months). (4) Conclusions: Tracheal resections for locally advanced tumor infiltration are feasible as an element of highly individualized treatment concepts.
(1) 背景：晚期甲状腺癌对气道消化道的浸润程度决定患者预后及生活质量。针对不同阶段的气管肿瘤侵犯，需制定个体化手术方案。(2) 方法：本研究为回顾性观察性研究，纳入2007年1月至2023年1月期间因晚期甲状腺癌接受气管切除手术的患者。系统记录手术切除方案及围手术期并发症，并对总生存期与切除后生存期进行分析。(3) 结果：2007至2023年间，美因茨大学医学中心共33例局部晚期甲状腺癌患者（女性15例，男性18例）接受颈部手术联合气管切除。其中14例接受非透壁性切除（气管削切术），19例接受透壁性切除（9例"窗式"切除、6例近环形切除、3例袖状切除、1例全喉切除联合食管黏膜外切除）。术后两年生存率为82.0%，两年无复发生存率为75.0%（平均随访时间29.2个月）。(4) 结论：针对局部晚期肿瘤浸润的气管切除术，可作为高度个体化治疗方案的重要组成部分，具有临床可行性。
A 16-Year Single-Center Series of Trachea Resections for Locally Advanced Thyroid Carcinoma
肿瘤(癌症)患者之家